Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Insights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomics
Δημιουργός/Συγγραφέας:	Moros, Georgios Boutsikou, Theodora Fotakis, Charalambos Iliodromiti, Zoe Sokou, Rozeta [EL] Κατσίλα, Θεοδώρα[EN] Katsila, Theodora Xanthos, Theodoros Iacovidou, Nicoletta [EL] Ζουμπουλάκης, Παναγιώτης[EN] Zoumpoulakis, Panagiotis
Εκδότης:	Springer Nature
Ημερομηνία:	2021-04-09
Γλώσσα:	Αγγλικά
ISSN:	2045-2322
DOI:	10.1038/s41598-021-87323-7
Άλλο:	33837233
Περίληψη:	Intrauterine growth restriction (IUGR) is a fetal adverse condition, ascribed by limited oxygen and nutrient supply from the mother to the fetus. Management of IUGR is an ongoing challenge because of its connection with increased fetal mortality, preterm delivery and postnatal pathologies. Untargeted nuclear magnetic resonance (1H NMR) metabolomics was applied in 84 umbilical cord blood and maternal blood samples obtained from 48 IUGR and 36 appropriate for gestational age (AGA) deliveries. Orthogonal projections to latent structures discriminant analysis (OPLS-DA) followed by pathway and enrichment analysis generated classification models and revealed significant metabolites that were associated with altered pathways. A clear association between maternal and cord blood altered metabolomic profile was evidenced in IUGR pregnancies. Increased levels of the amino acids alanine, leucine, valine, isoleucine and phenylalanine were prominent in IUGR pregnancies indicating a connection with impaired amino acid metabolism and transplacental flux. Tryptophan was individually connected with cord blood discrimination while 3-hydroxybutyrate assisted only maternal blood discrimination. Lower glycerol levels in IUGR samples ascribed to imbalance between gluconeogenesis and glycolysis pathways, suggesting poor glycolysis. The elevated levels of branched chain amino acids (leucine, isoleucine and valine) in intrauterine growth restricted pregnancies were linked with increased insulin resistance.
Τίτλος πηγής δημοσίευσης:	Scientific reports
Τόμος/Κεφάλαιο:	11
Τεύχος:	1
Σελίδες:	7824
Θεματική Κατηγορία:	[EL] Μαιευτική και γυναικολογία[EN] Gynecology and obstetrics [EL] Παθολογία[EN] Pathology [EL] Βιοχημεία[EN] Biochemistry [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Βιοπληροφορική[EN] Bioinformatics
Λέξεις-Κλειδιά:	3-Hydroxybutyric Acid Adult Amino Acids Female Fetal Blood Fetal Growth Retardation Gestational Age Glycerol Glycolysis Humans Infant, Newborn Insulin Resistance Male Metabolomics Middle Aged Pregnancy Proton Magnetic Resonance Spectroscopy Young Adult Metabolome
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2021 by the Authors
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.nature.com/articles/s41598-021-87323-7#rightslink
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.nature.com/srep/
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο