Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Biological evaluation of oil-in-water microemulsions as carriers of benzothiophene analogues for dermal applications
Δημιουργός/Συγγραφέας:	Theochari, Ioanna Ilic, Tanja Nicolic, Ines Dobricic, Vladimir Tenchiou, Alia [EL] Παπαχατζής, Δημήτρης Π.[EN] Papahatjis, Demetris P. Savic, Snezana [EL] Ξενάκης, Αριστοτέλης[EN] Xenakis, Aristotelis [EL] Παπαδημητρίου, Βασιλική[EN] Papadimitriou, Vassiliki [EL] Πλέτσα, Βασιλική[EN] Pletsa, Vassiliki
Εκδότης:	MDPI
Ημερομηνία:	2021-01-27
Γλώσσα:	Αγγλικά
ISSN:	2313-7673
DOI:	10.3390/biomimetics6010010
Άλλο:	33514031
Περίληψη:	During the last decade, many studies have been reported on the design and formulation of novel drug delivery systems proposed for dermal or transdermal administration. The efforts focus on the development of biocompatible nanodispersions that can be delivered to the skin and treat severe skin disorders, including cancer. In this context, oil-in-water (O/W) microemulsions have been developed to encapsulate and deliver lipophilic bioactive molecules for dermal application. An O/W biocompatible microemulsion composed of PBS buffer, Tween 80, and triacetin was assessed for its efficacy as a drug carrier of DPS-2, a lead compound, initially designed in-house to inhibit BRAFV600E oncogenic kinase. The system was evaluated through both in vitro and ex vivo approaches. The cytotoxic effect, in the presence and absence of DPS-2, was examined through the thiazolyl blue tetrazolium bromide (MTT) cell proliferation assay using various cell lines. Further investigation through Western blotting revealed that cells died of necrosis. Porcine ear skin was used as a skin model to evaluate the degree of permeation of DPS-2 through skin and assess its retention. Through the ex vivo experiments, it was clarified that encapsulated DPS-2 was distributed within the full thickness of the stratum corneum (SC) and had a high affinity to hair follicles.
Τίτλος πηγής δημοσίευσης:	Biomimetics (Basel, Switzerland)
Τόμος/Κεφάλαιο:	6
Τεύχος:	1
Σελίδες:	10
Θεματική Κατηγορία:	[EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry [EL] Δερματολογια[EN] Dermatology [EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Κυτταρολογία[EN] Cytology [EL] Χημική τεχνολογία[EN] Chemical technolgy
Λέξεις-Κλειδιά:	Franz diffusion cell Cell viability Chemotherapy Differential tape stripping Drug delivery Skin permeation
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2021 by the Authors. Licensee MDPI, Basel, Switzerland.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/2313-7673/6/1/10
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.mdpi.com/journal/biomimetics
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο