Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Synthesis and antifouling activity evaluation of analogs of bromosphaerol, a brominated diterpene isolated from the red alga sphaerococcus coronopifolius
Δημιουργός/Συγγραφέας:	[EL] Προύσης, Κυριάκος[EN] Prousis, Kyriakos Kikionis, Stefanos Ioannou, Efstathia Morgana, Silvia Faimali, Marco Piazza, Veronica [EL] Καλογεροπούλου, Θεοδώρα[EN] Calogeropoulou, Theodora Roussis, Vassilios
Εκδότης:	MDPI
Ημερομηνία:	2021-12-22
Γλώσσα:	Αγγλικά
ISSN:	1660-3397
DOI:	10.3390/md20010007
Άλλο:	35049862
Περίληψη:	Marine biofouling is an epibiotic biological process that affects almost any kind of submerged surface, causing globally significant economic problems mainly for the shipping industry and aquaculture companies, and its prevention so far has been associated with adverse environmental effects for non-target organisms. Previously, we have identified bromosphaerol (1), a brominated diterpene isolated from the red alga Sphaerococcus coronopifolius, as a promising agent with significant antifouling activity, exerting strong anti-settlement activity against larvae of Amphibalanus (Balanus) amphitrite and very low toxicity. The significant antifouling activity and low toxicity of bromosphaerol (1) motivated us to explore its chemistry, aiming to optimize its antifouling potential through the preparation of a number of analogs. Following different synthetic routes, we successfully synthesized 15 structural analogs (2-16) of bromosphaerol (1), decorated with different functional groups. The anti-settlement activity (EC50) and the degree of toxicity (LC50) of the bromosphaerol derivatives were evaluated using cyprids and nauplii of the cirriped crustacean A. amphitrite as a model organism. Derivatives 2, 4, and 6-16 showed diverse levels of antifouling activity. Among them, compounds 9 and 13 can be considered as well-performing antifoulants, exerting their activity through a non-toxic mechanism.
Τίτλος πηγής δημοσίευσης:	Marine drugs Special Issue: Tribute to Dr. Guido Cimino’s 80th Birthday and His Outstanding Achievements on Marine Natural Products
Τόμος/Κεφάλαιο:	20
Τεύχος:	1
Σελίδες:	7
Θεματική Κατηγορία:	[EL] Υδατοκαλλιέργεια. Ιχθυοκαλλιέργεια[EN] Aquaculture. Fisheries. Angling [EL] Περιβαλλοντική υγεία[EN] Environmental health [EL] Χημική τεχνολογία[EN] Chemical technolgy [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Βιοτεχνολογία[EN] Biotechnology [EL] Μικροβιολογία[EN] Microbiology
Λέξεις-Κλειδιά:	Amphibalanus amphitrite Sphaerococcus coronopifolius Antifouling activity Bromosphaerol Synthetic analogs Animals Aquatic Organisms Biofouling Diterpenes Larva Lethal Dose 50 Thoracica Rhodophyta
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2021 by the Authors. Licensee MDPI, Basel, Switzerland
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/1660-3397/20/1/7
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.mdpi.com/journal/marinedrugs
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο