Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Curcumin derivatives as potential mosquito larvicidal agents against two mosquito vectors, culex pipiens and aedes albopictus
Δημιουργός/Συγγραφέας:	Matiadis, Dimitris Liggri, Panagiota G V Kritsi, Eftichia Tzioumaki, Niki [EL] Ζουμπουλάκης, Παναγιώτης[EN] Zoumpoulakis, Panagiotis Papachristos, Dimitrios P Balatsos, George Sagnou, Marina Michaelakis, Antonios
Εκδότης:	MDPI
Ημερομηνία:	2021-08-18
Γλώσσα:	Αγγλικά
ISSN:	1422-0067
DOI:	10.3390/ijms22168915
Άλλο:	34445622
Περίληψη:	Vector-borne diseases have appeared or re-emerged in many Southern Europe countries making the transmission of infectious diseases by mosquitoes (vectors) one of the greatest worldwide health threats. Larvicides have been used extensively for the control of Aedes (Stegomyia) albopictus (Skuse, 1895) (Diptera: Culicidae) and Culex pipiens Linnaeus, 1758 (Diptera: Culicidae) mosquitoes in urban and semi-urban environments, causing the increasing resistance of mosquitoes to commercial insecticides. In this study, 27 curcuminoids and monocarbonyl curcumin derivatives were synthesised and evaluated as potential larvicidal agents against Cx. pipiens and Ae. albopictus. Most of the compounds were more effective against larvae of both mosquito species. Four of the tested compounds, curcumin, demethoxycurcumin, curcumin-BF2 complex and a monocarbonyl tetramethoxy curcumin derivative exhibited high activity against both species. In Cx. pipiens the recorded LC50 values were 6.0, 9.4, 5.0 and 32.5 ppm, respectively, whereas in Ae. albopictus they exhibited LC50 values of 9.2, 36.0, 5.5 and 23.6 ppm, respectively. No conclusive structure activity relationship was evident from the results and the variety of descriptors values generated in silico provided some insight to this end.
Τίτλος πηγής δημοσίευσης:	International journal of molecular sciences
Τόμος/Κεφάλαιο:	22
Τεύχος:	16
Σελίδες:	8915
Θεματική Κατηγορία:	[EL] Ιατρική-Δημόσια υγεία[EN] Medicine - public aspects [EL] Χημικά προϊόντα: Παραγωγή, χρήση κλπ[EN] Chemicals: Manufacture, use etc. [EL] Χημική τεχνολογία[EN] Chemical technolgy [EL] Χημική Βιολογία[EN] Chemical Biology
Λέξεις-Κλειδιά:	Asian tiger mosquito Common house mosquito Curcumin Curcuminoids In silico descriptors Larvicidal Aedes Animals Anti-Inflammatory Agents, Non-Steroidal Culex Female Insecticides Larva Mosquito Vectors
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2021 by the Authors. Licensee MDPI, Basel, Switzerland
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/1422-0067/22/16/8915
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.mdpi.com/journal/ijms
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο