Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Significant improvement of stress and aging biomarkers using a novel stress management program with the cognitive restructuring method "Pythagorean Self-Awareness Intervention" in patients with type 2 diabetes mellitus and healthy adults
Δημιουργός/Συγγραφέας:	Athanasopoulou, Sophia Simos, Dimitrios Charalampopoulou, Maria Tentolouris, Nikolaos Kokkinos, Alexandros Bacopoulou, Flora Aggelopoulou, Elena Zigkiri, Eleni Chrousos, George P Darviri, Christina [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S.
Εκδότης:	Elsevier
Ημερομηνία:	2021-09
Γλώσσα:	Αγγλικά
ISSN:	00476374
DOI:	10.1016/j.mad.2021.111538
Άλλο:	34217756
Περίληψη:	Stress accelerates aging by affecting relevant cellular pathways including, among others, leucocyte telomere length (LTL) and proteasome levels. Their impaired function underlies several age-related and non-communicable conditions, such as type 2 diabetes mellitus. The aim of the present study was to investigate, for the first time, the dynamics of stress-related aging factors in the frame of a novel stress-management technique, the Pythagorean Self Awareness Intervention (PSAI), in healthy volunteers and adults with type 2 diabetes. To this end a cohort of 311 healthy volunteers was initially studied and LTL and proteasome levels were analysed in a subgroup of healthy volunteers and adults with type 2 diabetes who were enrolled in the PSAI, with regards to specific physio- and psychometric characteristics of the participants (baseline and post-intervention). We have found a significant improvement of aging biomarkers and of psycho-/bio-factors in all participants. More specifically, post-intervention, both healthy adults and patients with type 2 diabetes demonstrated improved LTL and proteasome levels. Significant improvements were also observed in psychometric, anthropometric and key metabolic features as well as in hair cortisol. In conclusion our results highlighted potential key targets of such interventions and prognostic tools for the assessment of aging pace in clinical practice.
Τίτλος πηγής δημοσίευσης:	Mechanisms of ageing and development
Τόμος/Κεφάλαιο:	198
Σελίδες:	111538
Θεματική Κατηγορία:	[EL] Ιατρική (Γενικά)[EN] Medicine (General) [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Βιοχημεία[EN] Biochemistry [EL] Στατιστική[EN] Statistics [EL] Ψυχολογία[EN] Psychology
Λέξεις-Κλειδιά:	Behavioural intervention Proteasome Stress management Stress physiology Telomeres Type 2 diabetes Anthropometry Cognitive Restructuring Female Hair Analysis Humans Hydrocortisone Leukocytes Male Middle Aged Psychometrics Aging Diabetes Mellitus, Type 2 Proteasome Endopeptidase Complex Stress, Psychological Telomere Homeostasis
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2021 Elsevier B.V. All rights reserved.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1016/j.mad.2021.111538
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.sciencedirect.com/journal/mechanisms-of-ageing-and-development
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο