Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Sex specific associations between in utero exposure to persistent organic pollutants and allergy-related outcomes in childhood: The Rhea Mother-Child Cohort (Crete, Greece)
Δημιουργός/Συγγραφέας:	Margetaki, Katerina Alexaki, Maria Vittorakis, Evangelos Roumeliotaki, Theano Leventakou, Vasiliki Bempi, Vicky Chalkiadaki, Georgia [EL] Κυρτόπουλος, Σωτήριος Α.[EN] Kyrtopoulos, Soterios A. Rantakokko, Panu Kiviranta, Hannu Stephanou, Euripides G Kogevinas, Manolis Chatzi, Leda Vafeiadi, Marina
Εκδότης:	Cambridge University Press
Ημερομηνία:	2022-10
Γλώσσα:	Αγγλικά
ISSN:	2040-1744 2040-1752
DOI:	10.1017/S2040174421000660
Άλλο:	34859763
Περίληψη:	Accumulating evidence suggests that in utero exposures can influence the development of the immune system. Few studies have investigated whether prenatal exposure to persistent organic pollutants (POPs) is associated with allergy-related phenotypes in childhood, nor explored sex differences. We examined the association between prenatal exposure to POPs and offspring allergic outcomes in early and mid-childhood. We included 682 mother-child pairs from the prospective birth cohort Rhea. We measured dichlorodiphenyldichloroethylene (DDE), hexachlorobenzene (HCB) and 6 polychlorinated biphenyl (PCB) congeners in maternal first trimester serum. Parents completed the questionnaires adapted from the International Study on Asthma and Allergy in Childhood (ISAAC) for allergy-related phenotypes when their children were 4 and 6 years old. We used Poisson regression models to estimate Risk Ratios. Prenatal HCB was associated with increased risk for rhinoconjunctivitis at 6 years (RR (95% CI): 2.5; (1.3, 4.8) for a doubling in the exposure). Among girls, prenatal DDE was associated with increased risk for current wheeze, current asthma and current rhinoconjunctivitis at 4 years (RR (95%CI): 1.4 (0.8, 2.6), 1.6 (1.1, 2.4) and 1.8 (1.0, 3.3) and p-interaction = 0.035, 0.027 and 0.059, respectively), with increased risk for current rhinoconjunctivitis at 6 years (RR (95%CI): 1.7 (0.7, 3.8) and p-interaction = 0.028) and total PCBs were associated with increased risk for current eczema at 4 years (RR (95%CI): 2.1 (1.1, 4.2) and p-interaction = 0.028). In boys, prenatal DDE was associated with decreased risk for current wheeze and current asthma at 4 years. Our findings suggest that even low levels of exposure to POPs prenatally may affect the development of childhood allergy-related outcomes in a sex and age-specific manner.
Τίτλος πηγής δημοσίευσης:	Journal of developmental origins of health and disease
Τόμος/Κεφάλαιο:	13
Τεύχος:	5
Σελίδες:	566 - 574
Θεματική Κατηγορία:	[EL] Μαιευτική και γυναικολογία[EN] Gynecology and obstetrics [EL] Περιβαλλοντική υγεία[EN] Environmental health [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Στατιστική[EN] Statistics [EL] Βιοχημεία[EN] Biochemistry
Λέξεις-Κλειδιά:	DDE HCB PCB Allergic disease Animals Dichlorodiphenyl Dichloroethylene Environmental Exposure Female Hexachlorobenzene Humans Male Mother-Child Relations Persistent Organic Pollutants Pregnancy Prospective Studies Respiratory Sounds Asthma Environmental Pollutants Hypersensitivity Polychlorinated Biphenyls Prenatal Exposure Delayed Effects Rheiformes
Τοπική Κάλυψη:	Greece
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2021 The Authors. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.cambridge.org/core/journals/journal-of-developmental-origins-of-health-and-disease/article/abs/sex-specific-associations-between-in-utero-exposure-to-persistent-organic-pollutants-and-allergyrelated-outcomes-in-childhood-the-rhea-motherchild-cohort-crete-greece/B39EA49A2BE3CC143ED98305AF98802F#access-block
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.cambridge.org/core/journals/journal-of-developmental-origins-of-health-and-disease
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο