Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	PCB cause global DNA hypomethylation of human peripheral blood monocytes in vitro
Δημιουργός/Συγγραφέας:	Vidali, Maria-Sofia Dailianis, Stefanos Vlastos, Dimitris [EL] Γεωργιάδης, Παναγιώτης[EN] Georgiadis, Panagiotis
Εκδότης:	Elsevier
Ημερομηνία:	2021-10
Γλώσσα:	Αγγλικά
ISSN:	13826689
DOI:	10.1016/j.etap.2021.103696
Άλλο:	34171487
Περίληψη:	We have recently reported significant associations between exposure to polychlorinated biphenyls (PCB) and alterations on genome-wide methylation of leukocyte DNA of healthy volunteers and provided evidence in support of an etiological link between the observed CpG methylation variations and chronic lymphocytic leukemia. The present study aimed to elucidate the effects of PCB in human lymphocytes' methylome in vitro. Therefore, U937 cells and human peripheral blood monocytes (PBMC) were exposed in vitro to the dioxin-like PCB-118, the non-dioxin-like PCB-153, and hexachlorobenzene (HCB) and thorough cytotoxicity, genotoxicity and global CpG methylation analyses were performed. All compounds currently tested did not show any consistent significant genotoxicity at all exposure periods and concentrations used. On the contrary, extensive dose-dependent hypomethylation was observed, even at low concentrations, in stimulated PBMC treated with PCB-118 and PCB-153 as well as a small but statistically significant hypomethylation in HCB-treated stimulated cells.
Τίτλος πηγής δημοσίευσης:	Environmental toxicology and pharmacology
Τόμος/Κεφάλαιο:	87
Σελίδες:	103696
Θεματική Κατηγορία:	[EL] Χημική Βιολογία[EN] Chemical Biology [EL] Κυτταρολογία[EN] Cytology [EL] Γενετική[EN] Genetics [EL] Βιοχημεία[EN] Biochemistry
Λέξεις-Κλειδιά:	Comet Cytotoxicity Epigenetics Genotoxicity Methylation PCB Adult Cell Survival DNA Damage DNA Methylation Environmental Pollutants Hexachlorobenzene Humans Leukocytes, Mononuclear Polychlorinated Biphenyls U937 Cells
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2021 Elsevier B.V. All rights reserved.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1016/j.etap.2021.103696
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.sciencedirect.com/journal/environmental-toxicology-and-pharmacology
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο