Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Natural and nature-derived products targeting human coronaviruses
Δημιουργός/Συγγραφέας:	Vougogiannopoulou, Konstantina Corona, Angela Tramontano, Enzo [EL] Αλέξης, Μιχαήλ Ν.[EN] Alexis, Michael N. Skaltsounis, Alexios-Leandros
Εκδότης:	MDPI
Ημερομηνία:	2021-01-16
Γλώσσα:	Αγγλικά
ISSN:	1420-3049
DOI:	10.3390/molecules26020448
Άλλο:	33467029
Περίληψη:	The ongoing pandemic of severe acute respiratory syndrome (SARS), caused by the SARS-CoV-2 human coronavirus (HCoV), has brought the international scientific community before a state of emergency that needs to be addressed with intensive research for the discovery of pharmacological agents with antiviral activity. Potential antiviral natural products (NPs) have been discovered from plants of the global biodiversity, including extracts, compounds and categories of compounds with activity against several viruses of the respiratory tract such as HCoVs. However, the scarcity of natural products (NPs) and small-molecules (SMs) used as antiviral agents, especially for HCoVs, is notable. This is a review of 203 publications, which were selected using PubMed/MEDLINE, Web of Science, Scopus, and Google Scholar, evaluates the available literature since the discovery of the first human coronavirus in the 1960s; it summarizes important aspects of structure, function, and therapeutic targeting of HCoVs as well as NPs (19 total plant extracts and 204 isolated or semi-synthesized pure compounds) with anti-HCoV activity targeting viral and non-viral proteins, while focusing on the advances on the discovery of NPs with anti-SARS-CoV-2 activity, and providing a critical perspective.
Τίτλος πηγής δημοσίευσης:	Molecules (Basel, Switzerland) Special Issue: Targeting Coronavirus Diseases by Synthetic Chemical Entities and Natural Products
Τόμος/Κεφάλαιο:	26
Τεύχος:	2
Σελίδες:	448
Θεματική Κατηγορία:	[EL] Φαρμακευτική[EN] Pharmacy and materia medica [EL] Βιοχημεία[EN] Biochemistry [EL] Βάσεις δεδομένων[EN] Databases [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Μικροβιολογία[EN] Microbiology [EL] Βιοτεχνολογία[EN] Biotechnology
Λέξεις-Κλειδιά:	ACE2 MERS-CoV SARS-CoV Antiviral agents Antiviral protease inhibitors Coronavirus Cytopathic effect Natural products Phytochemicals Virus-host interactome Antiviral Agents Biological Products Coronavirus 229E, Human Coronavirus Infections Drug Evaluation, Preclinical Host-Pathogen Interactions Humans Middle East Respiratory Syndrome Coronavirus Severe acute respiratory syndrome-related coronavirus SARS-CoV-2 Viral Proteins
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2021 by the Authors. Licensee MDPI, Basel, Switzerland
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/1420-3049/26/2/448
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.mdpi.com/journal/molecules
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο