Εξειδίκευση τύπου :	Κεφάλαιο βιβλίου
Τίτλος:	Autophagy in aging and oxidative stress
Δημιουργός/Συγγραφέας:	Ranti, Dimitra Gioran, Anna [EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki
Επιμελητής έκδοσης:	[EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki Pick, Elah Gioran, Anna
Εκδότης:	CRC Press Taylor & Francis
Τόπος έκδοσης:	Boca Raton
Ημερομηνία:	2021
Γλώσσα:	Αγγλικά
ISBN:	9780367499327 (hbk) 9780367499334 (pbk) 9781003048138 (ebk)
DOI:	10.1201/9781003048138-17
Περίληψη:	Autophagy is an evolutionarily conserved catabolic process with a fundamental role in cellular content turnover and energy provision. Damaged or aggregated proteins as well as compromised organelles are removed from the cell through the autophagic machinery. Numerous studies have established the protective role of autophagy against the consequences of oxidative stress and specifically in the clearance of oxidized macromolecules and damaged organelles. Additionally, elevated reactive oxygen species (ROS) levels can activate autophagy either via transcriptional or translational modifications, eventually triggering a response that attenuates cell damage. It is also well established that autophagy declines with aging, thereby contributing to the perturbed protein homeostasis. Indeed, impaired autophagy is tightly associated with the early onset of neurodegenerative and age-related diseases. On the other hand, activation of autophagy is sufficient to promote longevity and healthspan across multiple animal models. This chapter summarizes the basic molecular mechanisms underlying autophagy and focuses on its roles in oxidative stress and aging.
Τίτλος πηγής δημοσίευσης:	Proteostasis and Proteolysis
Σελίδες:	225-252
Θεματική Κατηγορία:	[EL] Κυτταρολογία[EN] Cytology [EL] Βιολογία (Γενικά)[EN] Biology (General) [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Βιοχημεία[EN] Biochemistry
Λέξεις-Κλειδιά:	Autophagy Oxidative stress Reactive oxygen species (ROS) Aging Neurodegenerative diseases Longevity Proteasome Age-related diseases Mitochondria
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2022 Selection and editorial matter, Niki Chondrogianni, Elah Pick and Anna Gioran; Individual chapters, The contributors
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.taylorfrancis.com/books/edit/10.1201/9781003048138/proteostasis-proteolysis-niki-chondrogianni-elah-pick-anna-gioran
Είναι μέρος του:	Proteostasis and proteolysis
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο