Εξειδίκευση τύπου :	Κεφάλαιο βιβλίου
Τίτλος:	Proteasome fate in aging and proteinopathies
Δημιουργός/Συγγραφέας:	Vasilopoulou, Mary A. Papaevgeniou, Nikoletta [EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki
Επιμελητής έκδοσης:	[EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki Pick, Elah Gioran, Anna
Εκδότης:	CRC Press Taylor & Francis
Τόπος έκδοσης:	Boca Raton
Ημερομηνία:	2021
Γλώσσα:	Αγγλικά
ISBN:	9780367499327 (hbk) 9780367499334 (pbk) 9781003048138 (ebk)
DOI:	10.1201/9781003048138-12
Περίληψη:	Organisms have “safety valves” to maintain the integrity of their proteome. The protein homeostasis (proteostasis) network (PN) works accurately to facilitate the proper balance between protein synthesis and clearance. There is a gradual loss of protein quality control during aging progression due to the impairment of various proteostatic mechanisms. Disruption of proteostasis leads to aberrant accumulation of misfolded proteins that are targets of the cellular degradation machineries; the ubiquitin–proteasome system (UPS) and the autophagy-lysosomal pathway (ALP). Due to the age-related dysfunction of both UPS and ALP, misfolded proteins remain undegradable and form toxic aggregates that further inhibit the proteasome and negatively affect autophagy. This vicious cycle further aggravates the manifestation of various age-related protein-misfolding diseases (PMDs). This chapter shortly discusses the protective mechanisms of protein quality control and mainly focuses on the UPS. Since UPS impairment is associated with PMD progression, we refer to the UPS status in aging and age-related diseases and its implication in selected PMD pathology. We also discuss the interventions that have been performed toward proteasome activation as a promising therapeutic approach for the treatment of the major PMDs, such as various neurodegenerative diseases.
Τίτλος πηγής δημοσίευσης:	Proteostasis and Proteolysis
Σελίδες:	151-166
Θεματική Κατηγορία:	[EL] Κυτταρολογία[EN] Cytology [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Βιοχημεία[EN] Biochemistry [EL] Παθολογία[EN] Pathology [EL] Βιολογία (Γενικά)[EN] Biology (General) [EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry
Λέξεις-Κλειδιά:	Ubiquitin–proteasome system (UPS) Autophagy-lysosomal pathway (ALP) Autophagy Protein-misfolding diseases (PMDs) Neurodegenerative diseases Proteostasis Misfolded proteins Age-related diseases Cellular degradation machineries Protein quality control
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2022 Selection and editorial matter, Niki Chondrogianni, Elah Pick and Anna Gioran; Individual chapters, The contributors
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.taylorfrancis.com/books/edit/10.1201/9781003048138/proteostasis-proteolysis-niki-chondrogianni-elah-pick-anna-gioran
Είναι μέρος του:	Proteostasis and proteolysis
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο