Εξειδίκευση τύπου :	Κεφάλαιο βιβλίου
Τίτλος:	Transcriptional regulation of proteostatic mechanisms
Δημιουργός/Συγγραφέας:	Kapetanou, Marianna Athanasopoulou, Sophia [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S.
Επιμελητής έκδοσης:	[EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki Pick, Elah Gioran, Anna
Εκδότης:	CRC Press Taylor & Francis
Τόπος έκδοσης:	Boca Raton
Ημερομηνία:	2021
Γλώσσα:	Αγγλικά
ISBN:	9780367499327 (hbk) 9780367499334 (pbk) 9781003048138 (ebk)
DOI:	10.1201/9781003048138-03
Περίληψη:	A functional proteome is critical for all biological functions, organismal viability and longevity. Eukaryotic cells have developed highly sophisticated systems to constantly monitor and secure proteome fidelity that are referred as the proteostasis network (PN). This network dynamically coordinates protein synthesis, folding, modification and degradation, And responds to proteotoxic stress to either rescue or degrade misfolded or non-native polypeptides. The PN dynamically adapts to meet cellular requirements and to prevent proteostasis imbalance through integrated processes involving the regulation of transcriptional programs that act to promote and maintain proteome integrity, by curating the expression of molecular chaperones, proteolytic machineries and of other factors in response to diverse signals. This chapter focuses on the transcriptional regulation of the heat shock response (HSR), the oxidative stress response, the unfolded protein response (UPR) and of the main proteolytic machineries, namely the ubiquitin-proteasome system (UPS) and autophagy. The understanding of PN regulation is instrumental for the development of novel approaches to delay the onset of age-related pathologies associated with proteome deterioration and for extending human healthspan.
Τίτλος πηγής δημοσίευσης:	Proteostasis and Proteolysis
Σελίδες:	31-44
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General) [EL] Κυτταρολογία[EN] Cytology [EL] Βιοχημεία[EN] Biochemistry [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Παθολογία[EN] Pathology
Λέξεις-Κλειδιά:	Heat Shock Response (HSR) Oxidative Stress Response (OSR) Unfolded Protein Response (UPR) Ubiquitin-proteasome system (UPS) Autophagy-lysosomal pathway (ALP) Proteostasis network (PN) Autophagy Proteotoxic stress Proteolytic machineries Transcriptional regulation
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2022 Selection and editorial matter, Niki Chondrogianni, Elah Pick and Anna Gioran; Individual chapters, The contributors
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.taylorfrancis.com/books/edit/10.1201/9781003048138/proteostasis-proteolysis-niki-chondrogianni-elah-pick-anna-gioran
Είναι μέρος του:	Proteostasis and proteolysis
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο