Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Infective endocarditis by Klebsiella species: A systematic review
Δημιουργός/Συγγραφέας:	Ioannou, Petros Miliara, Eugenia Baliou, Stella Kofteridis, Diamantis P
Εκδότης:	Taylor & Francis
Ημερομηνία:	2021-10
Γλώσσα:	Αγγλικά
ISSN:	1120-009X 1973-9478
DOI:	10.1080/1120009X.2021.1888025
Άλλο:	33602044
Περίληψη:	This study aimed to systematically analyze all cases of infective endocarditis (IE) by Klebsiella species in the literature. A systematic review of PubMed, Scopus and Cochrane library (through 27th January 2021) for studies providing epidemiological, clinical, microbiological as well as treatment data and outcomes of IE by Klebsiella species was performed. In this review, a total of 66 studies were included, providing data for 67 patients. A prosthetic valve was present in 16.4%, while the most common causative pathogen was K. pneumoniae followed by K. oxytoca. The aortic valve was the most commonly infected intracardiac site, followed by the mitral valve. The diagnosis was based on transthoracic echocardiography in 46.2%, while the diagnosis was set at autopsy in 9.2% of included patients. Blood cultures were positive in 93.8%. Fever and sepsis were the most frequent clinical presentations, followed by embolic phenomena, paravalvular abscess, and heart failure. Cephalosporins, aminoglycosides, and carbapenems were the most frequently used antimicrobials. Surgical treatment along with antimicrobials was performed in 37.3% of included patients. Clinical cure was noted in 80.3%, while the overall mortality was 19.4%. Infection at the aortic valve was independently associated with mortality by IE. This systematic review gives a comprehensive description of IE by Klebsiella and provides information on epidemiology, clinical manifestations, therapeutic strategies and their outcomes.
Τίτλος πηγής δημοσίευσης:	Journal of chemotherapy (Florence, Italy)
Τόμος/Κεφάλαιο:	33
Τεύχος:	6
Θεματική Κατηγορία:	[EL] Μικροβιολογία[EN] Microbiology [EL] Βιοχημεία[EN] Biochemistry [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Φαρμακευτική[EN] Pharmacy and materia medica [EL] Ιατρική[EN] Medicine
Λέξεις-Κλειδιά:	Endocarditis Klebsiella Antimicrobial susceptibility Systematic review Anti-Bacterial Agents Aortic Valve Blood Culture Echocardiography Endocarditis, Bacterial Heart Valve Prosthesis Humans Klebsiella Infections Risk Factors
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2021 Informa UK Limited
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1080/1120009X.2021.1888025
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.tandfonline.com/journals/yjoc20
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο