Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Oxidative stress and neurodegeneration: Interconnected processes in polyQ diseases
Δημιουργός/Συγγραφέας:	Gkekas, Ioannis Gioran, Anna Boziki, Marina Kleopatra Grigoriadis, Nikolaos [EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki Petrakis, Spyros
Εκδότης:	MDPI
Ημερομηνία:	2021-09-13
Γλώσσα:	Αγγλικά
ISSN:	2076-3921
DOI:	10.3390/antiox10091450
Άλλο:	34573082
Περίληψη:	Neurodegenerative polyglutamine (polyQ) disorders are caused by trinucleotide repeat expansions within the coding region of disease-causing genes. PolyQ-expanded proteins undergo conformational changes leading to the formation of protein inclusions which are associated with selective neuronal degeneration. Several lines of evidence indicate that these mutant proteins are associated with oxidative stress, proteasome impairment and microglia activation. These events may correlate with the induction of inflammation in the nervous system and disease progression. Here, we review the effect of polyQ-induced oxidative stress in cellular and animal models of polyQ diseases. Furthermore, we discuss the interplay between oxidative stress, neurodegeneration and neuroinflammation using as an example the well-known neuroinflammatory disease, Multiple Sclerosis. Finally, we review some of the pharmaceutical interventions which may delay the onset and progression of polyQ disorders by targeting disease-associated mechanisms.
Τίτλος πηγής δημοσίευσης:	Antioxidants (Basel, Switzerland) Special Issue: Redox Systems, Oxidative Stress, and Antioxidant Defences in Health and Disease
Τόμος/Κεφάλαιο:	10
Τεύχος:	9
Σελίδες:	1450
Θεματική Κατηγορία:	[EL] Θεραπευτική. Φαρμακολογία[EN] Therapeutics.Pharmacology [EL] Βιοχημεία[EN] Biochemistry [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Παθολογία[EN] Pathology [EL] Κυτταρολογία[EN] Cytology
Λέξεις-Κλειδιά:	Microglia activation Neurodegeneration Neuroinflammation Oxidative stress Polyglutamine Proteasome impairment
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2021 by the Authors. Licensee MDPI, Basel, Switzerland.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/2076-3921/10/9/1450
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.mdpi.com/journal/antioxidants
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο