Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Protective role of taurine against oxidative stress (Review)
Δημιουργός/Συγγραφέας:	Baliou, Stella Adamaki, Maria Ioannou, Petros Pappa, Aglaia Panayiotidis, Mihalis I [EL] Σπαντίδος, Δημήτριος Α.[EN] Spandidos, Demetrios A. Christodoulou, Ioannis Kyriakopoulos, Anthony M [EL] Ζουμπουρλής, Βασίλης[EN] Zoumpourlis, Vassilis
Εκδότης:	Spandidos Publications
Ημερομηνία:	2021-08
Γλώσσα:	Αγγλικά
DOI:	10.3892/mmr.2021.12242
Άλλο:	34184084
Περίληψη:	Taurine is a fundamental mediator of homeostasis that exerts multiple roles to confer protection against oxidant stress. The development of hypertension, muscle/neuro‑​associated disorders, hepatic cirrhosis, cardiac dysfunction and ischemia/reperfusion are examples of some injuries that are linked with oxidative stress. The present review gives a comprehensive description of all the underlying mechanisms of taurine, with the aim to explain its anti‑oxidant actions. Taurine is regarded as a cytoprotective molecule due to its ability to sustain normal electron transport chain, maintain glutathione stores, upregulate anti‑oxidant responses, increase membrane stability, eliminate inflammation and prevent calcium accumulation. In parallel, the synergistic effect of taurine with other potential therapeutic modalities in multiple disorders are highlighted. Apart from the results derived from research findings, the current review bridges the gap between bench and bedside, providing mechanistic insights into the biological activity of taurine that supports its potential therapeutic efficacy in clinic. In the future, further clinical studies are required to support the ameliorative effect of taurine against oxidative stress.
Τίτλος πηγής δημοσίευσης:	Molecular medicine reports
Τόμος/Κεφάλαιο:	24
Τεύχος:	2
Σελίδες:	605
Θεματική Κατηγορία:	[EL] Χημική Βιολογία[EN] Chemical Biology [EL] Φυσιολογία[EN] Physiology [EL] Κυτταρολογία[EN] Cytology [EL] Παθολογία[EN] Pathology [EL] Βιοχημεία[EN] Biochemistry [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Θεραπευτική. Φαρμακολογία[EN] Therapeutics.Pharmacology
Λέξεις-Κλειδιά:	Cardiotoxicity Hepatotoxicity Neurotoxicity Oxidative stress Taurine Therapeutic Animals Antioxidants Heart Diseases Homeostasis Humans Liver Diseases Muscular Diseases Nervous System Diseases
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2021 Spandidos Publications
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.spandidos-publications.com/10.3892/mmr.2021.12242
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.spandidos-publications.com/mmr
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο