Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Ameliorative effect of taurine against diabetes and renal-associated disorders (Review)
Δημιουργός/Συγγραφέας:	Baliou, Stella Adamaki, Maria Ioannou, Petros Pappa, Aglaia Panayiotidis, Mihalis I Christodoulou, Ioannis [EL] Σπαντίδος, Δημήτριος Α.[EN] Spandidos, Demetrios A. Kyriakopoulos, Anthony M [EL] Ζουμπουρλής, Βασίλης[EN] Zoumpourlis, Vassilis
Εκδότης:	Spandidos Publications
Ημερομηνία:	2021
Γλώσσα:	Αγγλικά
DOI:	10.3892/mi.2021.3
Άλλο:	36699147
Περίληψη:	To develop novel therapeutic methods for both diabetic and renal disorders, scientists had initially focused on elucidating the molecular mechanisms of taurine in established cell lines and mouse models. Although a large amount of data have been revealed, taurine has been confirmed to be the next step of novel promising therapeutic interventions against diabetic disorders. Taurine appears to ameliorate diabetes 1-related complications in various organs through its antioxidant, anti-inflammatory and anti-hormonal actions. In type 2 diabetes, taurine has been positively implicated in glucose homeostasis, exerting potent hypoglycemic, anti-obesity, hypotensive and hypolipidemic effects. Of particular interest is that taurine provides protection against renal dysfunction, including hypertension and proteinuria, specific glomerular and tubular disorders, acute and chronic renal conditions, and diabetic nephropathy. The ameliorative effects of taurine against renal disorders are based on its osmoregulatory properties, its association with signaling pathways and its association with the renin-angiotensin-aldosterone system (RAAS). Further clinical studies are required to ensure the importance of research findings.
Τίτλος πηγής δημοσίευσης:	Medicine international
Τόμος/Κεφάλαιο:	1
Τεύχος:	3
Θεματική Κατηγορία:	[EL] Βιοχημεία[EN] Biochemistry [EL] Κυτταρολογία[EN] Cytology [EL] Παθολογία (Γενικά)[EN] Medicine (General) [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Θεραπευτική. Φαρμακολογία[EN] Therapeutics.Pharmacology
Λέξεις-Κλειδιά:	Diabetes Diabetic nephropathy Renal transplatation Taurine
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2021 Spandidos Publications
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.spandidos-publications.com/10.3892/mi.2021.3
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.spandidos-publications.com/mi
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο