Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Thermoresponsive chimeric nanocarriers as drug delivery systems
Δημιουργός/Συγγραφέας:	Naziris, Nikolaos Pippa, Natassa Skandalis, Athanasios Miłowska, Katarzyna Balcerzak, Łucja [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Bryszewska, Maria Demetzos, Costas
Ημερομηνία:	2021-12
Γλώσσα:	Αγγλικά
ISSN:	09277765
DOI:	10.1016/j.colsurfb.2021.112141
Άλλο:	34624599
Περίληψη:	Chimeric or mixed nanosystems belong to the class of advanced therapeutics. Their distinctive characteristic compared with other types of nanoparticles is that they combine two or more different classes of biomaterials. These platforms have created a promising and versatile field of nanomedicine, incorporating materials that are biocompatible, such as lipids, but also functional, such as stimuli-responsive polymers. In the present work, thermoresponsive chimeric nanocarriers composed of l-α-phosphatidylcholine (Egg, Chicken) (EPC) phospholipids and poly(N-isopropylacrylamide)-b-poly(lauryl acrylate) (PNIPAM-b-PLA) block copolymers were designed and developed. Initially, model lipid bilayers with incorporated polymers and drug molecule TRAM-34 were built and studied for their thermodynamics, in order to assess the stability and functionality of the systems. Chimeric nanoparticles of EPC and PNIPAM-b-PLA were then developed and evaluated for their physicochemical properties in different medium conditions, as well as for their morphology. Polymer incorporation led to alterations in the properties and morphology of the nanoparticles, while interactions with serum proteins were absent. TRAM-34 was also incorporated inside the developed nanocarriers, followed by incorporation and release studies, which revealed the functionality of the system in elevated temperature conditions. Finally, in vitro studies on normal cells suggest the biocompatibility of these nanosystems. The proposed platforms are promising for further studies and applications in vitro and in vivo.
Τίτλος πηγής δημοσίευσης:	Colloids and surfaces. B, Biointerfaces
Τόμος/Κεφάλαιο:	208
Σελίδες:	112141
Θεματική Κατηγορία:	[EL] Βιοχημεία[EN] Biochemistry [EL] Νανοτεχνολογία[EN] Nanotechnology
Λέξεις-Κλειδιά:	Amphiphilic copolymers Chimeric liposomes Controlled release TRAM-34 Thermoresponsive Drug Delivery Systems Lipid Bilayers Phospholipids Liposomes Polymers
Κάτοχος πνευματικών δικαιωμάτων:	© 2021 Elsevier B.V. All rights reserved
Σημειώσεις:	The research work was supported by the Hellenic Foundation for Research and Innovation (HFRI) and the General Secretariat for Research and Innovation (GSRI), under the HFRI PhD Fellowship grant to N.N. (GA. no. 392) and by the Polish National Agency for Academic Exchange (NAWA PROM), under the Project Named “International scholarship exchange of PhD Candidates and Academic Staff”. The authors would also like to express their gratitude to Professor Christina Limatola from the Department of Physiology and Pharmacology, Sapienza University of Rome and to Professor Heike Wulff from the Department of Pharmacology, University of California for providing the drug molecule TRAM-34.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο