Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Multi-responsive poly(oligo(ethylene glycol)methyl methacrylate)-co-poly(2-(diisopropylamino)ethyl methacrylate) hyperbranched copolymers via reversible addition fragmentation chain transfer polymerization
Δημιουργός/Συγγραφέας:	Selianitis, Dimitrios [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios
Εκδότης:	Royal Society of Chemistry
Ημερομηνία:	2021
Γλώσσα:	Αγγλικά
ISSN:	1759-9954 1759-9962
DOI:	10.1039/D1PY01320C
Περίληψη:	In this work, we report on the synthesis and self-organization in aqueous media of a series of novel multiresponsive poly(oligo(ethylene glycol)methyl methacrylate)-co-poly(2 (diisopropylamino)ethyl methacrylate), P(OEGMA-co-DIPAEMA), hyperbranched copolymers, using ethylene glycol dimethacrylate (EGDMA) units as branching points. Three P(OEGMA-co-DIPAEMA) hyperbranched copolymers with different ratios of hydrophilic to hydrophobic components are prepared by the reversible addition–fragmentation chain transfer (RAFT) polymerization, in order to study their properties in aqueous solutions. By using dynamic light scattering (DLS), the formation of aggregates with dimensions in the nanoscale, responsive to changes in solution temperature and pH, is observed. The hyperbranched copolymer with the lowest DIPAEMA hydrophobic component shows the largest dimensions at pH 7 and pH 10 compared to the other two copolymers. The hyperbranched copolymers are capable of encapsulating the hydrophobic drug curcumin (CUR) and demonstrate stability in the presence of serum proteins. These new hyperbranched copolymers could be potential candidates for drug delivery and bio-imaging applications.
Τίτλος πηγής δημοσίευσης:	Polymer Chemistry
Τόμος/Κεφάλαιο:	12
Τεύχος:	45
Σελίδες:	6582-6593
Θεματική Κατηγορία:	[EL] Φασματοσκοπία[EN] Spectroscopy [EL] Χημική τεχνολογία[EN] Chemical technolgy [EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry
Λέξεις-Κλειδιά:	Response characteristic Copolymerization Dynamic light scattering (DLS) Drug delivery systems Aggregate
Όροι και προϋποθέσεις δικαιωμάτων:	This article is Open Access
Ηλεκτρονική διεύθυνση με ανοικτή πρόσβαση (link):	https://pubs.rsc.org/en/content/articlelanding/2021/PY/D1PY01320C
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο