Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Amphiphilic AxBymikto-arm star copolymers with PLMAand POEGMA arms: Self-assembly and drug encapsulation
Δημιουργός/Συγγραφέας:	Vlassi, Eleni [EL] Παπαγιαννόπουλος, Αριστείδης[EN] Papagiannopoulos, Aristeidis [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios
Εκδότης:	John Wiley & Sons, Ltd
Ημερομηνία:	2021
Γλώσσα:	Αγγλικά
ISSN:	2642-4150 2642-4169
DOI:	10.1002/pol.20210082
Περίληψη:	We report on the synthesis and self-assembly of amphiphilic mikto-arm star copolymers of the AxBy type with mixed arms of poly(lauryl methacrylate) and poly(oligo ethylene glycol methacrylate). Two star copolymers with different hydrophobic-to-hydrophilic ratios are prepared in order to study their self-assembly in aqueous media. Both stars organize in structures with dimensions in the nanoscale. The star with the lower hydrophobic content forms aggregates of lower size and molar mass and it has a higher critical aggregation concentration. The synthesized mikto-arm stars are able to encapsulate curcumin (CUR) and preserve its fluorescence properties while their self-organization is affected by the incorporation of the hydrophobic drug compound. Interestingly, the more hydrophilic star is more strongly affected by the presence of CUR in terms of aggregate size and mass. In phosphate buffered saline (PBS) and fetal bovine serum-PBS solutions the star with higher hydrophobic content appears to better preserve its monomodal size distribution in comparison to the star with lower hydrophobic content either with or without encapsulated CUR. This work opens possibilities for using the new star copolymers in the solubilization of hydrophobic compounds and the delivery of hydrophobic drugs for pharmaceutical and bioimaging applications.
Τίτλος πηγής δημοσίευσης:	Journal of Polymer Science
Τόμος/Κεφάλαιο:	59
Τεύχος:	9
Σελίδες:	775 - 786
Θεματική Κατηγορία:	[EL] Βιοχημεία[EN] Biochemistry [EL] Φασματοσκοπία[EN] Spectroscopy [EL] Νανοτεχνολογία[EN] Nanotechnology [EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry
Λέξεις-Κλειδιά:	Amphiphilic Curcumin Light scattering Mikto-arm copolymers Star copolymers
EU Grant identifier:	MIS: 5002772
Κάτοχος πνευματικών δικαιωμάτων:	© 2021 Wiley Periodicals LLC
Σημειώσεις:	NSRF 2014-2020 co-financed by Greece and the European Union (European Regional Development Fund)., Grant/Award Number: MIS 5002772
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο