Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Viscoelasticity and Noise Properties Reveal the Formation of Biomemory in Cells
Δημιουργός/Συγγραφέας:	Bakalis, Evangelos Gavriil, Vassilios [EL] Κεφαλάς, Αλκιβιάδης Κωνσταντίνος[EN] Cefalas, Alciviadis Constantinos [EL] Κόλλια, Ζωή[EN] Kollia, Zoe Zerbetto, Francesco [EL] Σαραντοπούλου, Ευαγγελία[EN] Sarantopoulou, Evangelia
Εκδότης:	American Chemical Society
Ημερομηνία:	2021-10-07
Γλώσσα:	Αγγλικά
ISSN:	1520-6106 1520-5207
DOI:	10.1021/acs.jpcb.1c01752
Άλλο:	34546052
Περίληψη:	Living cells are neither perfectly elastic nor liquid and return a viscoelastic response to external stimuli. Nanoindentation provides force-distance curves, allowing the investigation of cell mechanical properties, and yet, these curves can differ from point to point on the cell surface, revealing its inhomogeneous character. In the present work, we propose a mathematical method to estimate both viscoelastic and noise properties of cells as these are depicted on the values of the scaling exponents of relaxation function and power spectral density, respectively. The method uses as input the time derivative of the response force in a nanoindentation experiment. Generalized moments method and/or rescaled range analysis is used to study the resulting time series depending on their nonstationary or stationary nature. We conducted experiments in living Ulocladium chartarum spores. We found that spores in the approaching phase present a viscoelastic behavior with the corresponding scaling exponent in the range 0.25-0.52 and in the retracting phase present a liquid-like behavior with exponents in the range 0.67-0.85. This substantial difference of the scaling exponents in the two phases suggests the formation of biomemory as a response of the spores to the indenting AFM mechanical stimulus. The retracting phase may be described as a process driven by bluish noises, while the approaching one is driven by persistent noise.
Τίτλος πηγής δημοσίευσης:	The Journal of Physical Chemistry B
Τόμος/Κεφάλαιο:	125
Τεύχος:	39
Σελίδες:	10883–10892
Θεματική Κατηγορία:	[EL] Βιοχημεία[EN] Biochemistry [EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry
Λέξεις-Κλειδιά:	Alternaria Microscopy, Atomic Force Viscosity Elasticity Cells Materials Deformation Circuit Color
EU Grant identifier:	MIS 5002735 MIS 5002409
Κάτοχος πνευματικών δικαιωμάτων:	© 2021 The Authors. Published by American Chemical Society
Ηλεκτρονική διεύθυνση με ανοικτή πρόσβαση (link):	https://pubs.acs.org/doi/10.1021/acs.jpcb.1c01752#
Σημειώσεις:	This work was funded under the frame of the projects “ELI−LASERLAB Europe Synergy, HiPER and IPERION-CH.gr” (MIS 5002735) which is implemented under the Action “Reinforcement of the Research and Innovation Infrastructure”, funded by the Operational Programme “Competitiveness, Entrepreneurship and Innovation” (NSRF 2014−2020) and co-financed by Greece and the European Union (European Regional Development Fund) and “Advanced Materials and Devices” (MIS 5002409) which is implemented under the “Action for the Strategic Development on the Research and Technological Sector”, funded by the Operational Programme “Competitiveness, Entrepreneurship and Innovation” (NSRF 2014−2020) and co-financed by Greece and the European Union (European Regional Development Fund).
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο