Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Chimeric liposomes incorporating functional copolymers: preparation and pH/thermo-responsive behaviour in aqueous solutions
Δημιουργός/Συγγραφέας:	Sentoukas, Theodore Demetzos, Costas [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios
Ημερομηνία:	2021
Γλώσσα:	Αγγλικά
ISSN:	0898-2104 1532-2394
DOI:	10.1080/08982104.2020.1806873
Άλλο:	33590785
Περίληψη:	The purpose of this study is to prepare stimuli-responsive chimeric liposomes (i.e. hybrid polymer-lipid liposomes) containing functional copolymers and conduct aqueous solution studies in order to determine their properties and potential as drug-delivery nanocarriers. Two random copolymers, composed of the hydrophilic, pH and thermo-responsive 2-(dimethyl amino) ethyl methacrylate (DMAEMA) monomer and the hydrophobic stearyl methacrylate (SMA) monomer, were synthesized via free-radical polymerization and molecularly characterized using SEC, FTIR, and 1H-NMR. The synthesis was followed by aqueous solution studies, utilising dynamic light scattering (DLS) in order to determine their stimuli responsive self-assembly properties. The preparation of chimeric liposomes was mediated by thin film deposition and hydration, followed by aqueous solution studies via DLS, ζ-potential and fluorescence spectroscopy. The drug-loading studies include curcumin loading via a thin film deposition and hydration technique, while aqueous solution properties of the drug-loaded chimeric liposomes were determined utilizing DLS, and UV-Vis spectroscopy.
Τίτλος πηγής δημοσίευσης:	Journal of Liposome Research
Τόμος/Κεφάλαιο:	31
Τεύχος:	3
Σελίδες:	279-290
Θεματική Κατηγορία:	[EL] Χημεία (Γενικά)[EN] Chemistry (General) [EL] Βιοχημεία[EN] Biochemistry [EL] Φασματοσκοπία[EN] Spectroscopy
Λέξεις-Κλειδιά:	Chimeric liposomes Light scattering pH-responsive copolymers Thermoresponsive copolymer
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.tandfonline.com/doi/full/10.1080/08982104.2020.1806873?scroll=top&needAccess=true&role=tab
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο