Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Polyethylene Oxide Hydrogels Crosslinked by Peroxide for the Controlled Release of Proteins
Δημιουργός/Συγγραφέας:	[EL] Παπαγιαννόπουλος, Αριστείδης[EN] Papagiannopoulos, Aristeidis Vlassi, Eleni [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Tsitsilianis, Constantinos Radulescu, Aurel
Ημερομηνία:	2020
Γλώσσα:	Αγγλικά
ISSN:	2673-6209
DOI:	10.3390/macromol1010004
Περίληψη:	Crosslinking of polyethylene oxide (PEO) using a peroxide in the melt is employed to synthesize soft hydrogels with the ability of controlled release of proteins. The viscoelastic properties of the swollen networks confirm the elastic nature of the synthesized material and they are in agreement with swelling characteristics. The hydrogels have mesh sizes at the nm scale as it is estimated by swelling measurements and measured by small angle neutron scattering (SANS). Diffusion of bovine serum albumin (BSA) and lysozyme (LYZ) out of the hydrogels is restricted by the presence of the network. The diffusion coefficient in the hydrogels is lower for BSA in comparison to LYZ, while in both cases it drops as the mesh size of the network becomes smaller. This study introduces the use of peroxide-crosslinked PEO networks in the investigation of protein transport within hydrogels, thedevelopment of hydrogel-based protein delivery patches and polymeric constructs.
Τίτλος πηγής δημοσίευσης:	Macromol
Τόμος/Κεφάλαιο:	1
Τεύχος:	1
Σελίδες:	37-48
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Χημική τεχνολογία[EN] Chemical technolgy [EL] Βιοχημεία[EN] Biochemistry
Λέξεις-Κλειδιά:	Small angle neutron scattering Diffusion Mesh-size Network Rheology
Κάτοχος πνευματικών δικαιωμάτων:	© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο