Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	The Influence of Hydrophobic Blocks of PEO-Containing Copolymers on Glyceryl Monooleate Lyotropic Liquid Crystalline Nanoparticles for Drug Delivery
Δημιουργός/Συγγραφέας:	Forys, Aleksander Chountoulesi, Maria Mendrek, Barbara Konieczny, Tomasz Sentoukas, Theodore Godzierz, Marcin Kordyka, Aleksandra Demetzos, Costas [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Trzebicka, Barbara
Ημερομηνία:	2021-08-05
Γλώσσα:	Αγγλικά
ISSN:	2073-4360
DOI:	10.3390/polym13162607
Άλλο:	34451146
Περίληψη:	The investigation of properties of amphiphilic block copolymers as stabilizers for non-lamellar lyotropic liquid crystalline nanoparticles represents a fundamental issue for the formation, stability and upgraded functionality of these nanosystems. The aim of this work is to use amphiphilic block copolymers, not studied before, as stabilizers of glyceryl monooleate 1-(cis-9-octadecenoyl)-rac-glycerol (GMO) colloidal dispersions. Nanosystems were prepared with the use of poly(ethylene oxide)-b-poly(lactic acid) (PEO-b-PLA) and poly(ethylene oxide)-b-poly(5-methyl-5-ethyloxycarbonyl-1,3-dioxan-2-one) (PEO-b-PMEC) block copolymers. Different GMO:polymer molar ratios lead to formulation of nanoparticles with different size and internal organization, depending on the type of hydrophobic block. Resveratrol was loaded into the nanosystems as a model hydrophobic drug. The physicochemical and morphological characteristics of the prepared nanosystems were investigated by dynamic light scattering (DLS), cryogenic transmission electron microscopy (cryo-TEM), fast Fourier transform (FFT) analysis and X-ray diffraction (XRD). The studies allowed the description of the lyotropic liquid crystalline nanoparticles and evaluation of impact of copolymer composition on these nanosystems. The structures formed in GMO:block copolymer colloidal dispersions were compared with those discussed previously. The investigations broaden the toolbox of polymeric stabilizers for the development of this type of hybrid polymer/lipid nanostructures.
Τίτλος πηγής δημοσίευσης:	Polymers
Τόμος/Κεφάλαιο:	13
Τεύχος:	16
Σελίδες:	2607
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Νανοτεχνολογία[EN] Nanotechnology [EL] Φασματοσκοπία[EN] Spectroscopy
Λέξεις-Κλειδιά:	Amphiphilic block copolymers Lipidic lyotropic liquid crystals Cryogenic transmission electron microscopy Fast Fourier transform Dynamic light scattering (DLS) X-ray diffraction (XRD) Resveratrol Lipid/polymer carriers
Κάτοχος πνευματικών δικαιωμάτων:	© 2021 by the authors. Licensee MDPI, Basel, Switzerland
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Ηλεκτρονική διεύθυνση με ανοικτή πρόσβαση (link):	https://www.mdpi.com/2073-4360/13/16/2607
Σημειώσεις:	This work was supported by state funds for the Centre of Polymer and Carbon Materials, Polish Academy of Sciences.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο