Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Reversible multilayered vesicle-like structures with fluid hydrophobic and interpolyelectrolyte layers
Δημιουργός/Συγγραφέας:	Murmiliuk, Anastasiia Filippov, Sergey K. Rud, Oleg Košovan, Peter Tošner, Zdeněk Radulescu, Aurel Skandalis, Athanasios [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Šlouf, Miroslav Štěpánek, Miroslav
Ημερομηνία:	2021
Γλώσσα:	Αγγλικά
ISSN:	00219797
DOI:	10.1016/j.jcis.2021.04.050
Περίληψη:	Hydrophobic blocks of amphiphilic block copolymers often form glassy micellar cores at room temperature with a rigid structure that limits their applications as nanocapsules for targeted delivery. Nevertheless, we prepared and analyzed core/shell micelles with a soft core, formed by a self-assembled block copolymer consisting of a hydrophobic block and a polycation block, poly(lauryl acrylate)-block-poly(trimethyl-aminoethyl acrylate) (PLA-QPDMAEA), in aqueous solution. By light and small-angle neutron scattering, by transmission electron microscopy and by fluorescence spectroscopy, we showed that these core/shell micelles are spherical and cylindrical with a fluid-like PLA core and a positively charged outer shell and that they can encapsulate and release hydrophobic solutes. Moreover, after mixing these PLA-QPDMAEA core/shell micelles with another diblock copolymer, consisting of a hydrophilic block and a polyanion block, namely poly(ethylene oxide)-block-poly(methacrylic acid) (PEO-PMAA), we observed the formation of novel vesicle-like multicompartment structures containing both soft hydrophobic and interpolyelectrolyte (IPEC) layers. By combining small-angle neutron scattering with self-consistent field modeling, we confirmed the formation of these complex vesicle-like structures with a swollen PEO core, an IPEC inner layer, a PLA soft layer, an IPEC outer layer and a loose PEO corona. Thus, these multicompartment micelles with fluid and IPEC layers and a hydrophilic corona may be used as nanocapsules with several tunable properties, including the ability to control the thickness of each layer, the charge of the IPEC layers and the stability of the micelles, to deliver both hydrophobic and multivalent solutes.
Τίτλος πηγής δημοσίευσης:	Journal of Colloid and Interface Science
Τόμος/Κεφάλαιο:	599
Σελίδες:	313-325
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Νανοτεχνολογία[EN] Nanotechnology [EL] Χημεία (Γενικά)[EN] Chemistry (General)
Λέξεις-Κλειδιά:	Block polyelectrolytes Core/shell particles Electrostatic coassembly Small-angle scattering
EU Grant identifier:	No.1375219 No.19-10429S No. UNCE/SCI/014 No. CZ.02.1.01/0.0/0.0/15_003/0000417-CUCAM No 731019 (EUSMI) Project No. SC-4621
Κάτοχος πνευματικών δικαιωμάτων:	© 2021 Elsevier Inc. All rights reserved.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.sciencedirect.com/science/article/pii/S002197972100552X
Σημειώσεις:	This research was supported by the Grant agency of the Charles University (GAUK), project No.1375219, by the Czech Science foundation, project No.19-10429S, by the Charles University Research Centre (Program No. UNCE/SCI/014) and by the Ministry of Education, Youth and Sports of the Czech Republic, Operational Program Research, Development and Education: ”Excellent Research Teams”, Project No. CZ.02.1.01/0.0/0.0/15_003/0000417-CUCAM. This project was also funded from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 731019 (EUSMI) to access to the KWS-2 instrument operated by JCNS at the Heinz Maier-Leibnitz Zentrum (MLZ), Garching, Germany. The authors also thank the European Synchrotron Radiation Facility (ESRF), Grenoble, France for granting SAXS beam time (Project No. SC-4621 at the ID02 beamline). The help of Dr. Ewa Pavlova with cryo-TEM experiments and Dr. Carlos V. Melo with proofreading the manuscript is also gratefully acknowledged.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο