Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Nano-Assemblies from Amphiphilic PnBA-b-POEGA Copolymers as Drug Nanocarriers
Δημιουργός/Συγγραφέας:	Chroni, Angeliki [EL] Μαυρομούστακος, Θωμάς[EN] Mavromoustakos, Thomas [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios
Ημερομηνία:	2021-04-05
Γλώσσα:	Αγγλικά
ISSN:	2073-4360
DOI:	10.3390/polym13071164
Άλλο:	33916421
Περίληψη:	The focus of this study is the development of highly stable losartan potassium (LSR) polymeric nanocarriers. Two novel amphiphilic poly(n-butyl acrylate)-block-poly(oligo(ethylene glycol) methyl ether acrylate) (PnBA-b-POEGA) copolymers with different molecular weight (Mw) of PnBA are synthesized via reversible addition fragmentation chain transfer (RAFT) polymerization, followed by the encapsulation of LSR into both PnBA-b-POEGA micelles. Based on dynamic light scattering (DLS), the PnBA30-b-POEGA70 and PnBA27-b-POEGA73 (where the subscripts denote wt.% composition of the components) copolymers formed micelles of 10 nm and 24 nm in water. The LSR-loaded PnBA-b-POEGA nanocarriers presented increased size and greater mass nanostructures compared to empty micelles, implying the successful loading of LSR into the inner hydrophobic domains. A thorough NMR (nuclear magnetic resonance) characterization of the LSR-loaded PnBA-b-POEGA nanocarriers was conducted. Strong intermolecular interactions between the biphenyl ring and the butyl chain of LSR with the methylene signals of PnBA were evidenced by 2D-NOESY experiments. The highest hydrophobicity of the PnBA27-b-POEGA73 micelles contributed to an efficient encapsulation of LSR into the micelles exhibiting a greater value of %EE compared to PnBA30-b-POEGA70 + 50% LSR nanocarriers. Ultrasound release profiles of LSR signified that a great amount of the encapsulated LSR is strongly attached to both PnBA30-b-POEGA70 and PnBA27-b-POEGA73 micelles.
Τίτλος πηγής δημοσίευσης:	Polymers
Τόμος/Κεφάλαιο:	13
Τεύχος:	7
Θεματική Κατηγορία:	[EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry [EL] Φασματοσκοπία[EN] Spectroscopy [EL] Νανοτεχνολογία[EN] Nanotechnology
Λέξεις-Κλειδιά:	Amphiphilic block copolymers Polymeric nanocarriers Drug delivery systems Thin film hydration method Drug encapsulation Drug release profile Drug–polymer intermolecular interactions
EU Grant identifier:	CERIC 20187056
Κάτοχος πνευματικών δικαιωμάτων:	© 2021 by the authors. Licensee MDPI, Basel, Switzerland
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article.
Ηλεκτρονική διεύθυνση με ανοικτή πρόσβαση (link):	https://www.mdpi.com/2073-4360/13/7/1164
Σημειώσεις:	Materials were supported by the National Kapodistrian University of Athens (NKUA). NMR experiments were supported by CERIC 20187056.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο