Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Antioxidant and antiaging properties of a novel synergistic nutraceutical complex: readouts from an In cellulo study and an in vivo prospective, randomized trial
Δημιουργός/Συγγραφέας:	Athanasopoulou, Sophia Kapetanou, Marianna Magouritsas, Michel Georges Mougkolia, Nikoletta Taouxidou, Polykseni Papacharalambous, Michael Sakellaridis, Fotios [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S.
Ημερομηνία:	2022-02-26
Γλώσσα:	Αγγλικά
ISSN:	2076-3921
DOI:	10.3390/antiox11030468
Άλλο:	35326118
Περίληψη:	Aging is a dynamic procedure that is developed in multiple layers and characterized by distinct hallmarks. The use of biomarkers that target different hallmarks of aging is substantial in predicting adverse outcomes during the aging process, implementing specifically designed antiaging interventions and monitoring responses to these interventions. The present study aimed to develop a novel composition of plant extracts, comprising identified active ingredients that synergistically target different hallmarks of aging in cellulo and in vivo. The selected single extracts and the developed composition were tested through a powerful set of biomarkers that we have previously identified and studied. The composition of selected extracts simultaneously increased cellular lifespan, reduced the cellular oxidative load and enhanced antioxidant defense mechanisms by increasing proteasome activity and content. In addition, the combination prevented telomere attrition and preserved optimum DNA methylation levels. Remarkably, biomarker profiling of healthy volunteers who received the identified combination in the form of a nutritional supplement within the frame of a prospective, randomized, controlled 3-month trial revealed an unprecedented antioxidant capacity in humans. In conclusion, our results support the notion that interventions with specifically designed combinations of natural compounds targeting multiple hallmarks of aging represent an effective way to improve healthspan and well-being.
Τίτλος πηγής δημοσίευσης:	Antioxidants (Basel, Switzerland)
Τόμος/Κεφάλαιο:	11
Τεύχος:	3
Θεματική Κατηγορία:	[EL] Γηριατρική[EN] Geriatrics [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Βιοχημεία[EN] Biochemistry
Λέξεις-Κλειδιά:	Antioxidant defense Dietary supplements Nutraceuticals Proteostasis Well-being
EU Grant identifier:	T1EDK-05165 MIS5031229 77f4dc3ddfc3a69f
Κάτοχος πνευματικών δικαιωμάτων:	© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/2076-3921/11/3/468
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο