Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Radiotherapy-Related Gene Signature in Prostate Cancer
Δημιουργός/Συγγραφέας:	Fortis, Sotirios P Goulielmaki, Maria Aubert, Nicolas Batsaki, Panagiota Ouzounis, Sotirios Cavouras, Dionisis Marodon, Gilles Stokidis, Savvas Gritzapis, Angelos D Baxevanis, Constantin N
Ημερομηνία:	2022-10-14
Γλώσσα:	Αγγλικά
ISSN:	2072-6694
DOI:	10.3390/cancers14205032
Άλλο:	36291815
Περίληψη:	Radiotherapy for localized prostate cancer has increased the cure and survival rates of patients. Besides its local tumoricidal effects, ionizing radiation has been linked to mechanisms leading to systemic immune activation, a phenomenon called the abscopal effect. In this study, we performed gene expression analysis on peripheral blood from prostate cancer patients obtained post- radiotherapy and showed that 6 genes, including CCR7, FCGR2B, BTLA, CD6, CD3D, and CD3E, were down-regulated by a range of 1.5-2.5-fold as compared to pre-radiotherapy samples. The expression of the signature consisting of these six genes was also significantly lower post- vs. pre-radiotherapy. These genes are involved in various tumor-promoting immune pathways and their down-regulation post-radiotherapy could be considered beneficial for patients. This is supported by the fact that low mRNA expression levels for the 6-gene signature in the prostate tumor tissue was linked to better survival. Importantly, we report that this 6-gene signature strongly correlated with a favorable prognosis regardless of poor standard clinicopathological parameters (i.e., Gleason score ≥ 8 and T3 (including T3a and T3b). Our pioneering data open the possibility that the 6-gene signature identified herein may have a predictive value, but this requires further long-term studies.
Τίτλος πηγής δημοσίευσης:	Cancers
Τόμος/Κεφάλαιο:	14
Τεύχος:	20
Θεματική Κατηγορία:	[EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Βιοχημεία[EN] Biochemistry [EL] Γενετική[EN] Genetics
Λέξεις-Κλειδιά:	Prostate cancer Radiotherapy Immune system Gene-expression Six-gene signature Predictive biomarkers
EU Grant:	RESEARCH–CREATE–INNOVATE
EU Grant identifier:	T1EDK-01404
Κάτοχος πνευματικών δικαιωμάτων:	© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/2072-6694/14/20/5032
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο