Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Bacterial DNAemia in Older Participants and Nonagenarian Offspring and Association With Redox Biomarkers: Results From MARK-AGE Study
Δημιουργός/Συγγραφέας:	Giacconi, Robertina D'Aquila, Patrizia Malavolta, Marco Piacenza, Francesco Bürkle, Alexander Villanueva, María Moreno Dollé, Martijn E T Jansen, Eugène Grune, Tilman [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. Franceschi, Claudio Capri, Miriam Gradinaru, Daniela Grubeck-Loebenstein, Beatrix Sikora, Ewa Stuetz, Wolfgang Weber, Daniela Toussaint, Olivier Debacq-Chainiaux, Florence Hervonen, Antti Hurme, Mikko Slagboom, P Eline Schön, Christiane Bernhardt, Jürgen Breusing, Nicolle Duncan, Talbot Passarino, Giuseppe Bellizzi, Dina Provinciali, Mauro
Ημερομηνία:	2023-01-26
Γλώσσα:	Αγγλικά
ISSN:	1079-5006 1758-535X
DOI:	10.1093/gerona/glac154
Άλλο:	35914804
Περίληψη:	Aging and age-related diseases have been linked to microbial dysbiosis with changes in blood bacterial DNA concentration. This condition may promote chronic low-grade inflammation, which can be further aggravated by antioxidant nutrient deficiency. Low plasma carotenoids are associated with an increased risk of inflammation and cellular damage and predict mortality. However, no evidence is yet available on the relationship between antioxidants and the blood bacterial DNA (BB-DNA). Therefore, this study aimed to compare BB-DNA from (a) GO (nonagenarian offspring), (b) age-matched controls (Randomly recruited Age-Stratified Individuals from the General population [RASIG]), and (c) spouses of GO (SGO) recruited in the MARK-AGE project, as well as to investigate the association between BB-DNA, behavior habits, Charlson Comorbidity Index (CCI), leucocyte subsets, and the circulating levels of some antioxidants and oxidative stress markers. BB-DNA was higher in RASIG than GO and SGO, whereas GO and SGO participants showed similar values. BB-DNA increased in smokers and males with CCI ≥ 2 compared with those with CCI ≤ 1 within RASIG. Moreover, BB-DNA was positively associated with lymphocyte, neutrophil, and monocyte counts, but not with self-reported dietary habits. Higher quartiles of BB-DNA were associated with low lutein and zeaxanthin and elevated malondialdehyde plasma concentrations in RASIG. BB-DNA was also positively correlated with nitric oxide levels. Herein, we provide evidence of a reduced BB-DNA in individuals from long-living families and their spouses, suggesting a decreased microbial dysbiosis and bacterial systemic translocation. BB-DNA was also associated with smoking, CCI, leukocyte subsets, and some redox biomarkers in older participants.
Τίτλος πηγής δημοσίευσης:	The journals of gerontology. Series A, Biological sciences and medical sciences
Τόμος/Κεφάλαιο:	78
Τεύχος:	1
Θεματική Κατηγορία:	[EL] Βιοχημεία[EN] Biochemistry [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Γενετική[EN] Genetics [EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	Aging Blood bacterial DNA Dysbiosis Inflammation Longevity
EU Grant:	MARK-AGE PROMISING: “aPpROccio alla MedIcina di preciSIoNe in Geriatria: dalle basi biomolecolari dell’ invecchiamento e delle malattie età correlate ai modelli clinico/assistenziali”
EU Grant identifier:	200880 RCR-2021-23671216—Cat.B-PRV-RETE AGING
Κάτοχος πνευματικών δικαιωμάτων:	© 2022 The Authors. Published by Oxford University Press on behalf of The Gerontological Society of America.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://academic.oup.com/biomedgerontology/article/78/1/42/6653118
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο