Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	The impact of radiation therapy on the TCR Vβ chain repertoire in patients with prostate cancer
Δημιουργός/Συγγραφέας:	Goulielmaki, Maria Davanos, Nikolaos Kogionou, Paraskevi Batsaki, Panagiota Stokidis, Savvas Adamaki, Maria Mosa, Eftychia Vasilakou, Evanthia Zambatis, Charalambos Gritzapis, Angelos D [EL] Ζουμπουρλής, Βασίλης[EN] Zoumpourlis, Vassilis Baxevanis, Constantin N Fortis, Sotirios P
Ημερομηνία:	2022-06
Γλώσσα:	Αγγλικά
ISSN:	1019-6439 1791-2423
DOI:	10.3892/ijo.2022.5361
Άλλο:	35445738
Περίληψη:	Radiation therapy (RT) is an essential component in the therapeutic treatment of patients with localized prostate cancer (LPCa). Besides its local effects, ionizing radiation has been linked to mechanisms leading to systemic immune activation. The present study explored the effect of RT on the T‑cell receptor variable β (TCR Vβ) chain repertoire of peripheral blood T cells in patients with LPCa. High‑throughput TCR Vβ sequencing was performed on 20 blood samples collected from patients with LPCa at baseline and 3 months post‑RT. The diversity index was altered, as were TCR Vβ clonal evenness and convergence before and post‑RT; however, these findings were not significant. Notably, marked changes in the frequencies among the top 10 TCR Vβ clonotypes were detected and some patients developed new clonotypes of high abundance. These data provided initial evidence that RT in patients with LPCa may induce systemic immune changes, which could be exploited by future therapies for improved clinical results.
Τίτλος πηγής δημοσίευσης:	International journal of oncology
Τόμος/Κεφάλαιο:	60
Τεύχος:	6
Θεματική Κατηγορία:	[EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Κυτταρολογία[EN] Cytology [EL] Βιοχημεία[EN] Biochemistry
Λέξεις-Κλειδιά:	T cell T‑cell receptor variable β Clonotype frequencies Prostate cancer Radiation therapy
EU Grant:	RESEARCH-CREATE-INNOVATE
EU Grant identifier:	T1EDK-01404
Κάτοχος πνευματικών δικαιωμάτων:	© 2022 Goulielmaki et al
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article distributed under the terms of Creative Commons Attribution License.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.spandidos-publications.com/10.3892/ijo.2022.5361#
Σημειώσεις:	Supplementary data are available in the Sequence Read Archive under BioProject no. PRJNA818160 (https://www.ncbi.nlm.nih.gov/bioproject/PRJNA818160).
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο