Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Transcriptional regulatory networks of the proteasome in mammalian systems
Δημιουργός/Συγγραφέας:	Kapetanou, Marianna Athanasopoulou, Sophia [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S.
Ημερομηνία:	2022-01
Γλώσσα:	Αγγλικά
ISSN:	1521-6543 1521-6551
DOI:	10.1002/iub.2586
Άλλο:	34958522
Περίληψη:	The tight regulation of proteostasis is essential for physiological cellular function. Mammalian cells possess a network of mechanisms that ensure proteome integrity under normal or stress conditions. The proteasome, being the major cellular proteolytic machinery, is central to proteostasis maintenance in response to distinct intracellular and extracellular conditions. The proteasomes are multisubunit protease complexes that selectively catalyze the degradation of short-lived regulatory proteins and damaged peptides. Different forms of the proteasome complexes comprising of different subunits and attached regulators directly affect the substrate selectivity and degradation. Thus, the proteasome participates in the turnover of a multitude of factors that control key processes that affect the cellular state, such as adaptation to environmental cues, growth, development, metabolism, signaling, senescence, pluripotency, differentiation, and immunity. Aberrations on its function are related to normal processes like aging and pathological conditions such as neurodegeneration and cancer. The past few years of research have highlighted that proteasome abundance, activity, assembly, and localization are subject to a dynamic transcriptional control that secures the continuous adaptation of the proteasome to internal or external stimuli. This review focuses on the factors and signaling pathways that are involved in the regulation of the mammalian proteasome at the transcriptional level. A comprehensive understanding of proteasome regulation has critical implications on disease prevention and treatment.
Τίτλος πηγής δημοσίευσης:	IUBMB life
Τόμος/Κεφάλαιο:	74
Τεύχος:	1
Θεματική Κατηγορία:	[EL] Βιοχημεία[EN] Biochemistry [EL] Γενετική[EN] Genetics [EL] Κυτταρολογία[EN] Cytology [EL] Φυσιολογία[EN] Physiology [EL] Χημική Βιολογία[EN] Chemical Biology
Λέξεις-Κλειδιά:	Aging Animals Gene Regulatory Networks Transcription Factors Mammals Proteasome Endopeptidase Complex
EU Grant:	PROTAGE PROTEOMAGE Operational Program Competitiveness, Entrepreneurship and Innovation Reinforcement of Postdoctoral Researchers—2nd Cycle Human Resources Development, Education and Lifelong Learning, Greece and the European Union
EU Grant identifier:	QLK6-CT-1999-02193 518230 MIS5031229 T1EDK-05165 MIS-5033021
Κάτοχος πνευματικών δικαιωμάτων:	© 2021 International Union of Biochemistry and Molecular Biology
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://iubmb.onlinelibrary.wiley.com/doi/10.1002/iub.2586
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο