Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Short-wave and near infrared π-conjugated polymers hosted in a biocompatible microemulsion: a pioneering approach for photoacoustic contrast agents
Δημιουργός/Συγγραφέας:	Mitsou, Evgenia Theochari, Ioanna Vassiliadi, Evdokia Nallet, Frédéric [EL] Ξενάκης, Αριστοτέλης[EN] Xenakis, Aristotelis
Ημερομηνία:	2022-04-06
Γλώσσα:	Αγγλικά
DOI:	10.1039/d1tb02257a
Άλλο:	35079759
Περίληψη:	In the present study a biocompatible oil-in-water (O/W) microemulsion was developed carrying short-wave infrared (SWIR) π-conjugated polymers and possessing photoacoustic properties for the first time. SWIR and NIR absorbing conjugated polymers were accomplished to be dissolved in a Food & Drug Administration (FDA) approved natural oil limonene, to formulate an O/W microemulsion using biocompatible surfactants (Span80, Labrasol®). Detailed structural characterization in the absence and presence of the polymers was performed by means of dynamic light scattering (DLS), small-angle X-ray scattering (SAXS) and electron paramagnetic resonance (EPR) spectroscopy. In terms of biological evaluation of the loaded microemulsions, inhibition of cell proliferation in various cancer cell lines without exhibiting significant cytotoxicity was tested through the MTT assay. The developed π-conjugated polymers hosted in O/W microemulsions represent a technological approach with a wide range of biomedical and bioelectronic applications and in this contribution, their photoacoustic properties are presented as a proof-of-concept.
Τίτλος πηγής δημοσίευσης:	Journal of materials chemistry. B
Τόμος/Κεφάλαιο:	10
Τεύχος:	14
Θεματική Κατηγορία:	[EL] Χημική Βιολογία[EN] Chemical Biology [EL] Φασματοσκοπία[EN] Spectroscopy [EL] Βιοιατρική μηχανική. Ηλεκτρονική. Ενοργάνιση[EN] Biomedical engineering. Electronics. Instrumentation [EL] Βιοτεχνολογία[EN] Biotechnology
Λέξεις-Κλειδιά:	Electron Spin Resonance Spectroscopy Emulsions Scattering, Small Angle X-Ray Diffraction Contrast Media Polymers
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article, licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://pubs.rsc.org/en/content/articlelanding/2022/TB/D1TB02257A
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο