Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Metal hypersensitivity and pro-inflammatory cytokine production in patients with failed orthopedic implants: A case-control study
Δημιουργός/Συγγραφέας:	Podzimek, Stepan Himmlova, Lucie Janatova, Tatjana Bjørklund, Geir Vrbova, Radka Janovska, Marketa Peana, Massimiliano [EL] Χασάπης, Χρήστος[EN] Chasapis, Christos Vinsu, Alex Prochazkova, Jarmila Duskova, Jana
Ημερομηνία:	2022-12
Γλώσσα:	Αγγλικά
ISSN:	15216616
DOI:	10.1016/j.clim.2022.109152
Άλλο:	36243347
Περίληψη:	Orthopedic implants heal well without complications in most patients but fail for unclear reasons in some individuals. This study determined the relevance of metal hypersensitivity in patients with failed orthopedic implants and those requiring orthopedic implant surgery. The study included 35 patients with failed orthopedic implants and 15 subjects scheduled for orthopedic implant surgery. The production of selected pro-inflammatory cytokines was measured in patients with failed orthopedic implants. Metal hypersensitivity was measured in all subjects using the MELISA® test. Of common metals in orthopedic alloys, the patients with failed orthopedic implants responded most frequently to nickel, chromium, titanium, iron, and molybdenum. Hypersensitivity to metals found in implants was measured in 40% of patients with failed implants. The study also showed that titanium exposure in patients with titanium hypersensitivity might lead to implant failure. Metal hypersensitivity testing should be offered to patients before surgery to minimize the risk of implant failure.
Τίτλος πηγής δημοσίευσης:	Clinical immunology (Orlando, Fla.)
Τόμος/Κεφάλαιο:	245
Θεματική Κατηγορία:	[EL] Χειρουργική[EN] Surgery [EL] Ανοσολογία[EN] Immunology [EL] Βιοχημεία[EN] Biochemistry [EL] Δημόσια υγεία. Υγιεινή. Προληπτική ιατρική[EN] Public health. Hygiene. Preventive medicine [EL] Χημική Βιολογία[EN] Chemical Biology
Λέξεις-Κλειδιά:	Cytokines Implant failure MELISA® Metal hypersensitivity Orthopedic implants
EU Grant identifier:	NV19-08-00070 207030
Κάτοχος πνευματικών δικαιωμάτων:	© 2022 The Authors. Published by Elsevier Inc.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.sciencedirect.com/science/article/pii/S1521661622002339?via%3Dihub#ks0005
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο