Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Self-Aggregation in Aqueous Media of Amphiphilic Diblock and Random Block Copolymers Composed of Monomers with Long Side Chains
Δημιουργός/Συγγραφέας:	Rappoport, Sapir Chrysostomou, Varvara Kafetzi, Martha [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Talmon, Yeshayahu
Ημερομηνία:	2023-03-07
Γλώσσα:	Αγγλικά
ISSN:	0743-7463 1520-5827
DOI:	10.1021/acs.langmuir.2c03294
Άλλο:	36802652
Περίληψη:	Amphiphilic diblock copolymers and hydrophobically modified random block copolymers can self-assemble into different structures in a selective solvent. The formed structures depend on the copolymer properties, such as the ratio between the hydrophilic and the hydrophobic segments and their nature. In this work, we characterize by cryogenic transmission electron microscopy (cryo-TEM) and dynamic light scattering (DLS) the amphiphilic copolymers poly(2-dimethylamino ethyl methacrylate)-b-poly(lauryl methacrylate) (PDMAEMA-b-PLMA) and their quaternized derivatives QPDMAEMA-b-PLMA at different ratios between the hydrophilic and the hydrophobic segments. We present the various structures formed by these copolymers, including spherical and cylindrical micelles, as well as unilamellar and multilamellar vesicles. We also examined by these methods the random diblock copolymers poly(2-(dimethylamino) ethyl methacrylate)-b-poly(oligo(ethylene glycol) methyl ether methacrylate) (P(DMAEMA-co-Q6/12DMAEMA)-b-POEGMA), which are partially hydrophobically modified by iodohexane (Q6) or iodododecane (Q12). The polymers with a small POEGMA block did not form any specific nanostructure, while a polymer with a larger POEGMA block formed spherical and cylindrical micelles. This nanostructural characterization could lead to the efficient design and use of these polymers as carriers of hydrophobic or hydrophilic compounds for biomedical applications.
Τίτλος πηγής δημοσίευσης:	Langmuir : the ACS journal of surfaces and colloids
Τόμος/Κεφάλαιο:	39
Τεύχος:	9
Σελίδες:	3380−3390
Θεματική Κατηγορία:	[EL] Νανοτεχνολογία[EN] Nanotechnology [EL] Βιοχημεία[EN] Biochemistry [EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry
Λέξεις-Κλειδιά:	Chemical structure Copolymers Dynamic light scattering (DLS) Hydrophilicity Hydrophobicity
EU Grant identifier:	Grant#2302/20 Fellowship Number: 799
Κάτοχος πνευματικών δικαιωμάτων:	© 2023 American Chemical Society
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://pubs.acs.org/doi/10.1021/acs.langmuir.2c03294
Σημειώσεις:	The supporting information is available at: https://pubs.acs.org/doi/10.1021/acs.langmuir.2c03294.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο