Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Tumor eradication by hetIL-15 locoregional therapy correlates with an induced intratumoral CD103intCD11b+ dendritic cell population
Δημιουργός/Συγγραφέας:	[EL] Στέλλας, Δημήτρης[EN] Stellas, Dimitris Karaliota, Sevasti Stravokefalou, Vasiliki Angel, Matthew Nagy, Bethany A Goldfarbmuren, Katherine C Bergamaschi, Cristina Felber, Barbara K Pavlakis, George N
Εκδότης:	Elsevier
Ημερομηνία:	2023-05-30
Γλώσσα:	Αγγλικά
ISSN:	22111247
DOI:	10.1016/j.celrep.2023.112501
Άλλο:	37178117
Περίληψη:	Locoregional monotherapy with heterodimeric interleukin (IL)-15 (hetIL-15) in a triple-negative breast cancer (TNBC) orthotopic mouse model resulted in tumor eradication in 40% of treated mice, reduction of metastasis, and induction of immunological memory against breast cancer cells. hetIL-15 re-shaped the tumor microenvironment by promoting the intratumoral accumulation of cytotoxic lymphocytes, conventional type 1 dendritic cells (cDC1s), and a dendritic cell (DC) population expressing both CD103 and CD11b markers. These CD103intCD11b+DCs share phenotypic and gene expression characteristics with both cDC1s and cDC2s, have transcriptomic profiles more similar to monocyte-derived DCs (moDCs), and correlate with tumor regression. Therefore, hetIL-15, a cytokine directly affecting lymphocytes and inducing cytotoxic cells, also has an indirect rapid and significant effect on the recruitment of myeloid cells, initiating a cascade for tumor elimination through innate and adoptive immune mechanisms. The intratumoral CD103intCD11b+DC population induced by hetIL-15 may be targeted for the development of additional cancer immunotherapy approaches.
Τίτλος πηγής δημοσίευσης:	Cell reports
Τόμος/Κεφάλαιο:	42
Τεύχος:	5
Θεματική Κατηγορία:	[EL] Ανοσολογία[EN] Immunology [EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Κυτταρολογία[EN] Cytology [EL] Βιοχημεία[EN] Biochemistry
Λέξεις-Κλειδιά:	CP: Cancer CP: Immunology IL-15 T cell memory breast cancer cytokines dendritic cells immonotherapy interleukin-15 mouse models Mice Animals Integrin alpha Chains Cytokines Dendritic Cells Lymphocytes Immunologic Factors Mice, Inbred C57BL Tumor Microenvironment Neoplasms Antineoplastic Agents
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	Elsevier
Ηλεκτρονική διεύθυνση με ανοικτή πρόσβαση (link):	https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00512-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124723005120%3Fshowall%3Dtrue
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο