Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Assessing the quality of stored red blood cells using handheld Spatially Offset Raman spectroscopy with multisource correlation analysis
Δημιουργός/Συγγραφέας:	Vardaki, Martha Z. Georg Schulze, H Serrano, Katherine Blades, Michael W Devine, Dana V F B Turner, Robin
Ημερομηνία:	2022-08-05
Γλώσσα:	Αγγλικά
ISSN:	13861425
DOI:	10.1016/j.saa.2022.121220
Άλλο:	35395462
Περίληψη:	In this work we employ Spatially Offset Raman Spectroscopy (SORS) to non-invasively identify storage-related changes in red blood cell concentrate (RCC) in-situ within standard plastic transfusion bags. To validate the measurements, we set up a parallel study comparing both bioanalytical data (obtained by blood-gas analysis, hematology analysis and spectrophotometric assays), and Raman spectrometry data from the same blood samples. We then employ Multisource Correlation Analysis (MuSCA) to correlate the different types of data in RCC. Our analysis confirmed a strong correlation of glucose, methemoglobin and oxyhemoglobin with their respective bioassay values in RCC units. Finally, by combining MuSCA with k-means clustering, we assessed changes in all Raman wavenumbers during cold storage in both RCC Raman data from the current study and parallel RCC supernatant Raman data previously acquired from the same units. Direct RCC quality monitoring during storage, would help to establish a basis for improved inventory management of blood products in blood banks and hospitals based on analytical data.
Τίτλος πηγής δημοσίευσης:	Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Τόμος/Κεφάλαιο:	276
Θεματική Κατηγορία:	[EL] Φασματοσκοπία[EN] Spectroscopy [EL] Τεχνολογία[EN] Technology [EL] Βιοπληροφορική[EN] Bioinformatics
Λέξεις-Κλειδιά:	Spatially Offset Raman spectroscopy Storage lesion 2D-COS Raman spectroscopy Multisource correlation analysis Red blood cell concentrate Inventory management Transfusion efficacy
Κάτοχος πνευματικών δικαιωμάτων:	© 2022 Elsevier B.V. All rights reserved.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.sciencedirect.com/science/article/pii/S1386142522003699?via%3Dihub#ak005
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο