Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Healthspan improvement and anti-aggregation effects induced by a marine-derived structural proteasome activator
Δημιουργός/Συγγραφέας:	Vasilopoulou, Mary A Gioran, Anna Theodoropoulou, Margarita Koutsaviti, Aikaterini Roussis, Vassilios Ioannou, Efstathia [EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki
Εκδότης:	Elsevier B.V.
Ημερομηνία:	2022-10
Γλώσσα:	Αγγλικά
ISSN:	22132317
DOI:	10.1016/j.redox.2022.102462
Άλλο:	36095970
Περίληψη:	Proteasome activation has been shown to promote cellular and organismal healthspan and to protect against aggregation-related conditions, such as Alzheimer's disease (AD). Various natural compounds have been described for their proteasome activating properties but scarce data exist on marine metabolites that often possess unique chemical structures, exhibiting pronounced bioactivities with novel mechanisms of action. In this study, we have identified for the first time a marine structural proteasome activator, namely (1R,3E,6R,7Z,11S,12S)-dolabella-3,7,18-trien-6,17-olide (DBTO). DBTO activates the 20S proteasome complex in cell-free assays but also in cellulo. Continuous supplementation of human primary fibroblasts with DBTO throughout their cellular lifespan confers an improved healthspan while ameliorated health status is also observed in wild type (wt) Caenorhabditis elegans (C. elegans) nematodes supplemented with DBTO. Furthermore, treatment of various AD nematode models, as well as of human cells of neuronal origin challenged with exogenously added Aβ peptide, with DBTO results in enhanced protection against Aβ-induced proteotoxicity. In total, our results reveal the first structural proteasome activator derived from the marine ecosystem and highlight its potential as a compound that might be used for healthspan maintenance and preventive strategies against proteinopathies, such as AD.
Τίτλος πηγής δημοσίευσης:	Redox biology
Τόμος/Κεφάλαιο:	56
Σελίδες:	102462
Θεματική Κατηγορία:	[EL] Βιοχημεία[EN] Biochemistry [EL] Δομική Βιολογία[EN] Structural Biology [EL] Βιοτεχνολογία[EN] Biotechnology
Λέξεις-Κλειδιά:	Algal diterpenes Alzheimer's disease Aβ-induced proteotoxicity Healthspan Marine compounds Structural proteasome activator
Κάτοχος πνευματικών δικαιωμάτων:	© 2022 The Authors
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.sciencedirect.com/science/article/pii/S2213231722002348?via%3Dihub#appsec1
Σημειώσεις:	supplementary material at: https://www.sciencedirect.com/science/article/pii/S2213231722002348?via%3Dihub#appsec1
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο