Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	The Role of the Thioredoxin System in Brain Diseases
Δημιουργός/Συγγραφέας:	Bjørklund, Geir Zou, Lili Peana, Massimiliano [EL] Χασάπης, Χρήστος[EN] Chasapis, Christos Hangan, Tony Lu, Jun Maes, Michael
Ημερομηνία:	2022-10-31
Γλώσσα:	Αγγλικά
ISSN:	2076-3921
DOI:	10.3390/antiox11112161
Άλλο:	36358532
Περίληψη:	The thioredoxin system, consisting of thioredoxin (Trx), thioredoxin reductase (TrxR), and NADPH, plays a fundamental role in the control of antioxidant defenses, cell proliferation, redox states, and apoptosis. Aberrations in the Trx system may lead to increased oxidative stress toxicity and neurodegenerative processes. This study reviews the role of the Trx system in the pathophysiology and treatment of Alzheimer's, Parkinson's and Huntington's diseases, brain stroke, and multiple sclerosis. Trx system plays an important role in the pathophysiology of those disorders via multiple interactions through oxidative stress, apoptotic, neuro-immune, and pro-survival pathways. Multiple aberrations in Trx and TrxR systems related to other redox systems and their multiple reciprocal relationships with the neurodegenerative, neuro-inflammatory, and neuro-oxidative pathways are here analyzed. Genetic and environmental factors (nutrition, metals, and toxins) may impact the function of the Trx system, thereby contributing to neuropsychiatric disease. Aberrations in the Trx and TrxR systems could be a promising drug target to prevent and treat neurodegenerative, neuro-inflammatory, neuro-oxidative stress processes, and related brain disorders.
Τίτλος πηγής δημοσίευσης:	Antioxidants (Basel, Switzerland)
Τόμος/Κεφάλαιο:	11
Τεύχος:	11
Θεματική Κατηγορία:	[EL] Φυσιολογία[EN] Physiology [EL] Παθολογία[EN] Pathology [EL] Βιοχημεία[EN] Biochemistry [EL] Δομική Βιολογία[EN] Structural Biology
Λέξεις-Κλειδιά:	Alzheimer’s disease Huntington’s disease Parkinson’s disease Antioxidants Metals Multiple sclerosis Oxidative stress Stroke
Κάτοχος πνευματικών δικαιωμάτων:	© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/2076-3921/11/11/2161
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο