Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Radiotherapy in Metastatic Urothelial Carcinoma: Rationale and Clinical Applications
Δημιουργός/Συγγραφέας:	Vassiliou, Vassilios [EL] Κατσίλα, Θεοδώρα[EN] Katsila, Theodora Sodergren, Samantha C Kardamakis, Dimitrios
Ημερομηνία:	2022-08
Γλώσσα:	Αγγλικά
ISSN:	0250-7005 1791-7530
DOI:	10.21873/anticanres.15867
Άλλο:	35896266
Περίληψη:	Urothelial carcinoma is the most common type of bladder cancer including upper urinary tract urothelial cell carcinoma (renal pelvis and ureters) and urethral carcinoma. It exhibits high mortality and morbidity rates and is usually diagnosed at a late, incurable stage, carrying a poor prognosis. Local symptoms in patients with metastatic urothelial carcinoma (mUC) have an adverse impact on quality of life (QoL) and are associated with frequent hospitalizations. Herein, we review the role of palliative radiotherapy in mUC as the means to ameliorate a wide range of symptoms, seeking optimum patient stratification, even though the latter should be balanced against any acute or late toxicity that may arise. For this, links to the molecular biology of mUC are explored and QoL assessments are presented. To maximize patient benefit from radiotherapy, we conclude that multi-modal datasets need to be re-visited to better inform multi-center studies where policy makers, health professionals, researchers, and patient groups meet. Radiotherapy either as a monotherapy or alongside systemic therapy may serve as an added value.
Τίτλος πηγής δημοσίευσης:	Anticancer research
Τόμος/Κεφάλαιο:	42
Τεύχος:	8
Θεματική Κατηγορία:	[EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Βιοχημεία[EN] Biochemistry [EL] Χημική Βιολογία[EN] Chemical Biology
Λέξεις-Κλειδιά:	Radiotherapy Metastatic urothelial Carcinoma Quality of lifereview
Κάτοχος πνευματικών δικαιωμάτων:	© 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
Όροι και προϋποθέσεις δικαιωμάτων:	Non-commercial use
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://ar.iiarjournals.org/content/42/8/3767
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://ar.iiarjournals.org/
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο