Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Current Treatments to Control African Trypanosomiasis and One Health Perspective
Δημιουργός/Συγγραφέας:	Venturelli, Alberto Tagliazucchi, Lorenzo Lima, Clara Venuti, Federica Malpezzi, Giulia Magoulas, George E Santarem, Nuno [EL] Καλογεροπούλου, Θεοδώρα[EN] Calogeropoulou, Theodora Cordeiro-da-Silva, Anabela Costi, Maria Paola
Εκδότης:	MDPI
Ημερομηνία:	2022-06-27
Γλώσσα:	Αγγλικά
ISSN:	2076-2607
DOI:	10.3390/microorganisms10071298
Άλλο:	35889018
Περίληψη:	Human African Trypanosomiasis (HAT, sleeping sickness) and Animal African Trypanosomiasis (AAT) are neglected tropical diseases generally caused by the same etiological agent, Trypanosoma brucei. Despite important advances in the reduction or disappearance of HAT cases, AAT represents a risky reservoir of the infections. There is a strong need to control AAT, as is claimed by the European Commission in a recent document on the reservation of antimicrobials for human use. Control of AAT is considered part of the One Health approach established by the FAO program against African Trypanosomiasis. Under the umbrella of the One Health concepts, in this work, by analyzing the pharmacological properties of the therapeutic options against Trypanosoma brucei spp., we underline the need for clearer and more defined guidelines in the employment of drugs designed for HAT and AAT. Essential requirements are addressed to meet the challenge of drug use and drug resistance development. This approach shall avoid inter-species cross-resistance phenomena and retain drugs therapeutic activity.
Τίτλος πηγής δημοσίευσης:	Microorganisms
Τόμος/Κεφάλαιο:	10
Τεύχος:	7
Θεματική Κατηγορία:	[EL] Επιδημίες. Επιδημιολογία[EN] Epidemics. Epidemiology [EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Μικροβιολογία[EN] Microbiology
Λέξεις-Κλειδιά:	Human African Trypanosomiasis Animal African trypanosomiasis Antitrypanosomal drugs Drugs mechanism of action One health approaches
EU Grant:	New Medicine for Trypanosomatidic infections POCI-01-0145-FEDER-031013
EU Grant identifier:	603240 PTDC/SAU-PAR/31013/2017 2020.07306
Κάτοχος πνευματικών δικαιωμάτων:	© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/2076-2607/10/7/1298
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο