Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Long COVID and neuropsychiatric manifestations (Review)
Δημιουργός/Συγγραφέας:	Efstathiou, Vasiliki Stefanou, Maria-Ioanna Demetriou, Marina Siafakas, Nikolaos Makris, Michael Tsivgoulis, Georgios [EL] Ζουμπουρλής, Βασίλης[EN] Zoumpourlis, Vassilis Kympouropoulos, Stylianos P. Tsoporis, James N [EL] Σπαντίδος, Δημήτριος Α.[EN] Spandidos, Demetrios A. Smyrnis, Nikolaos Rizos, Emmanouil
Ημερομηνία:	2022-05
Γλώσσα:	Αγγλικά
ISSN:	1792-0981 1792-1015
DOI:	10.3892/etm.2022.11290
Άλλο:	35493431
Περίληψη:	There is accumulating evidence in the literature indicating that a number of patients with coronavirus disease 2019 (COVID-19) may experience a range of neuropsychiatric symptoms, persisting or even presenting following the resolution of acute COVID-19. Among the neuropsychiatric manifestations more frequently associated with 'long COVID' are depression, anxiety, post-traumatic stress disorder, sleep disturbances, fatigue and cognitive deficits, that can potentially be debilitating and negatively affect patients' wellbeing, albeit in the majority of cases symptoms tend to improve over time. Despite variations in results obtained from studies using different methodological approaches to define 'long COVID' syndrome, the most widely accepted factors associated with a higher risk of developing neuropsychiatric manifestations include the severity of foregoing COVID-19, the female sex, the presence of comorbidities, a history of mental health disease and an elevation in the levels of inflammatory markers, albeit further research is required to establish causal associations. To date, the pathophysiological mechanisms implicated in neuropsychiatric manifestations of 'long COVID' remain only partially elucidated, while the role of the indirect effects of the COVID-19 pandemic, such as social isolation and uncertainty concerning social, financial and health recovery post-COVID, have also been highlighted. Given the alarming effects of 'long-COVID', interdisciplinary cooperation for the early identification of patients who are at a high risk of persistent neuropsychiatric presentations, beyond COVID-19 recovery, is crucial to ensure that appropriate integrated physical and mental health support is provided, with the aim of mitigating the risks of long-term disability at a societal and individual level.
Τίτλος πηγής δημοσίευσης:	Experimental and therapeutic medicine
Τόμος/Κεφάλαιο:	23
Τεύχος:	5
Θεματική Κατηγορία:	[EL] Επιδημίες. Επιδημιολογία[EN] Epidemics. Epidemiology [EL] Ιατρική-Δημόσια υγεία[EN] Medicine - public aspects [EL] Φυσιολογία[EN] Physiology [EL] Ιολογία[EN] Virology
Λέξεις-Κλειδιά:	COVID‑19 COVID-19 survivors Long COVID Neuropsychiatric sequalae Post‑COVID syndrome Severe acute respiratory syndrome coronavirus 2
Κάτοχος πνευματικών δικαιωμάτων:	© 2022 Efstathiou et al
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article distributed under the terms of Creative Commons Attribution License.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.spandidos-publications.com/10.3892/etm.2022.11290
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο