Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Role of endothelial dysfunction in the severity of COVID‑19 infection (Review)
Δημιουργός/Συγγραφέας:	Kadiyska, Tanya Tourtourikov, Ivan Dabchev, Kristiyan Cherneva, Radostina Stoynev, Nikolay Hadjiolova, Radka Mitev, Vanyo [EL] Σπαντίδος, Δημήτριος Α.[EN] Spandidos, Demetrios A. Adamaki, Maria [EL] Ζουμπουρλής, Βασίλης[EN] Zoumpourlis, Vassilis
Ημερομηνία:	2022-11
Γλώσσα:	Αγγλικά
ISSN:	1791-2997 1791-3004
DOI:	10.3892/mmr.2022.12867
Άλλο:	36196882
Περίληψη:	COVID‑19 patients with severe infection have been observed to have elevated auto‑antibodies (AAs) against angiotensin II receptor type 1 (AT1R) and endothelin (ET) 1 receptor type A (ETAR), compared with healthy controls and patients with favorable (mild) infection. AT1R and ETAR are G protein‑coupled receptors, located on vascular smooth muscle cells, fibroblasts, immune and endothelial cells, and are activated by angiotensin II (Ang II) and ET1 respectively. AAs that are specific for these receptors have a functional role similar to the natural ligands, but with a more prolonged vasoconstrictive effect. They also induce the production of fibroblast collagen, the release of reactive oxygen species and the secretion of proinflammatory cytokines (including IL‑6, IL‑8 and TNF‑α) by immune cells. Despite the presence of AAs in severe COVID‑19 infected patients, their contribution and implication in the severity of the disease is still not well understood and further studies are warranted. The present review described the major vascular homeostasis systems [ET and renin‑angiotensin‑aldosterone system (RAAS)], the vital regulative role of nitric oxide, the AAs, and finally the administration of angiotensin II receptor blockers (ARBs), so as to provide more insight into the interplay that exists among these components and their contribution to the severity, prognosis and possible treatment of COVID‑19.
Τίτλος πηγής δημοσίευσης:	Molecular medicine reports
Τόμος/Κεφάλαιο:	26
Τεύχος:	5
Θεματική Κατηγορία:	[EL] Επιδημίες. Επιδημιολογία[EN] Epidemics. Epidemiology [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Ανοσολογία[EN] Immunology [EL] Ιολογία[EN] Virology [EL] Ιατρική-Δημόσια υγεία[EN] Medicine - public aspects
Λέξεις-Κλειδιά:	COVID‑19 Renin‑angiotensin‑aldosterone system Angiotensin Angiotensin‑converting enzyme Endothelin Renin
Κάτοχος πνευματικών δικαιωμάτων:	© Kadiyska et al
Όροι και προϋποθέσεις δικαιωμάτων:	This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.spandidos-publications.com/10.3892/mmr.2022.12867
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο