Εξειδίκευση τύπου :	Κεφάλαιο βιβλίου
Τίτλος:	Applications of Nanotechnology in Alzheimer’s Disease
Δημιουργός/Συγγραφέας:	Chountoulesi, Maria Naziris, Nikolaos Gioran, Anna [EL] Παπαγιαννόπουλος, Αριστείδης[EN] Papagiannopoulos, Aristeidis [EL] Στηλ, Μπάρυ[EN] Steele, Barry R. [EL] Μίχα-Σκρέττα, Μαρία[EN] Micha-Screttas, Maria Stavrinides, Stavros G. Hanias, Michael [EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios [EL] Αρμπέζ-Ζιντρ, Σεσίλ[EN] Arbez-Gindre, Cecile Demetzos, Costas
Επιμελητής έκδοσης:	Vlamos, Panayiotis Kotsireas, Ilias S. Tarnanas, Ioannis
Εκδότης:	Springer, Cham
Ημερομηνία:	2022-06-25
Γλώσσα:	Γαλλικά
ISBN:	978-3-319-75479-6 (print) 978-3-319-75479-6 (online)
DOI:	10.1007/978-3-319-75479-6_16-1
Περίληψη:	Alzheimer’s disease (AD) is a neurodegenerative disorder, proved by the accumulation of extracellular amyloid (Aβ) plaques, leading to degeneration of vulnerable brain regions. Till today, the available marked approved medicines still focus on controlling the symptoms and slowing down the disease progression, but unfortunately not curing it. The low drug bioavailability, due to low ability of crossing the blood–brain barrier (BBB), hinders the efficacy of the existing therapies. However, nanotechnology has gained great scientific interest, providing alternative approaches to upgrade the AD treatments, such as by increasing the drug penetrating efficacy to BBB and drug bioavailability, by drug delivery nanosystems and minimizing the adverse effects. In the present chapter, the currently suggested theories on AD development and progression are presented, as well as the contribution of C. elegans AD models to understanding the disease’s mechanisms. Subsequently, the recent advances of nanotechnology in the treatment of AD are discussed, focusing on three different main nanosystem categories, namely polymer-based nanostructures, dendrimers, and lipidic nanosystems. Moreover, useful experimental methods towards the evaluation of the nanosystems and the study of amyloid formation are explored, including physicochemical methods as light scattering and nonlinear dynamic methods. Finally, the future perspectives of nanotechnology field to AD and the emerging challenges are highlighted.
Τίτλος πηγής δημοσίευσης:	Handbook of Computational Neurodegeneration
Σελίδες:	1-45
Θεματική Κατηγορία:	[EL] Νανοτεχνολογία[EN] Nanotechnology [EL] Φαρμακευτική τεχνολογία[EN] Pharmaceutical technology [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Βιοχημεία[EN] Biochemistry
Λέξεις-Κλειδιά:	Drug delivery nanosystems Polymers C. elegans Alzheimer’s disease (AD) Dendrimers Lipidic nanoparticles
Κάτοχος πνευματικών δικαιωμάτων:	© 2022 Springer Nature Switzerland AG
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://link.springer.com/referenceworkentry/10.1007/978-3-319-75479-6_16-1#copyright-information
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο