Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Poly(2-(dimethylamino) ethyl methacrylate)-b-poly(lauryl methacrylate)-bpoly(oligo ethylene glycol methacrylate) triblock terpolymer micelles as drug delivery carriers for curcumin
Δημιουργός/Συγγραφέας:	Skandalis, Athanasios Selianitis, Dimitrios Sory, David R. Rankin, Sara M. Jones, Julian R. [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios
Εκδότης:	Wiley
Ημερομηνία:	2022-10-10
Γλώσσα:	Αγγλικά
DOI:	10.1002/app.52899
Άλλο:	e52899
Περίληψη:	This work aims to investigate the ability of poly[2-(dimethylamino)ethyl methacrylate-b-lauryl methacrylate-b-(oligo ethylene glycol)methacrylate], PDMAEMA-b-PLMA-b-POEGMA amphiphilic triblock terpolymers, to encapsulate the model hydrophobic compound curcumin. The terpolymers were synthesized by RAFT polymerization methodologies at variable molecular weights and compositions and self-assemble into spherical micelles with mixed PDMAEMA/POEGMA coronas and PLMA cores, when inserted in aqueous solutions. Fourier transform infrared and UV–Vis spectroscopy measurements were utilized in order to confirm and quantify the encapsulation of curcumin within the polymeric micelles respectively. Dynamic light scattering was used for the investigation of the size of the nanostructures formed and transmission electron microscopy proved that their morphology is spherical. Moreover, the colloidal stability of the systems in physiological conditions was assessed and two independent in vitro cytotoxicity assays revealed that curcumin-loaded PDMAEMA-b-PLMA-b-POEGMA micelles were not cytotoxic.
Τίτλος πηγής δημοσίευσης:	Journal of Applied Polymer Science
Τόμος/Κεφάλαιο:	139
Τεύχος:	28
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Χημεία[EN] Chemistry
Λέξεις-Κλειδιά:	Biomedical applications Copolymers Drug delivery systems
Κάτοχος πνευματικών δικαιωμάτων:	2022 Wiley Periodicals LLC
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1002/app.52899
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο