Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Studying the properties of polymer-lipid nanostructures: The role of the host lipid
Δημιουργός/Συγγραφέας:	Chountoulesi, Maria Perinelli, Diego Romano Forys, Aleksander Katifelis, Hektor Selianitis, Dimitrios Chrysostomou, Varvara Lagopati, Nefeli Bonacucina, Giulia Trzebicka, Barbara Gazouli, Maria Demetzos, Costas [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Pippa, Natassa
Εκδότης:	Elsevier
Ημερομηνία:	2022-11
Γλώσσα:	Αγγλικά
DOI:	10.1016/j.jddst.2022.103830
Περίληψη:	The goal of the present investigation is to prepare polymer-grafted hybrid liposomes using phospholipids with different main transition temperature (Tm). In more detail, liposomes were prepared by the combination of three different lipids, having different transition temperatures, namely 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) with the amphiphilic block copolymer poly(2-(dimethylamino)ethyl methacrylate)-b-poly(lauryl methacrylate) (PDMAEMA-b-PLMA). The physicochemical characteristics of the prepared hybrid liposomes were evaluated by light scattering and their morphology by cryo-TEM. Their thermotropic behavior was characterized by mDSC and high-resolution ultrasound spectroscopy, while their microenvironmental parameters were attained by fluorescence spectroscopy. Subsequently, in vitro nanotoxicity studies have taken place. The studies indicate that PDMAEMA-b-PLMA was encapsulated in the liposomal membrane, leading size, and shape characteristics, as well as biosafety profile, strictly affected by the formulation's parameters, namely the lipid type and the polymer concentration. Thermal analysis confirmed the different interactions taking place between the polymer and the different lipids. The obtained results show that the aqueous heat method can be successfully used for lipid-polymer hybrid structures, containing lipids with a wide range of transition temperatures. These systems can also load curcumin, which was used as model active substance.
Τίτλος πηγής δημοσίευσης:	Journal of Drug Delivery Science and Technology
Τόμος/Κεφάλαιο:	77
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Βιοτεχνολογία[EN] Biotechnology
Λέξεις-Κλειδιά:	Liposomes Aqueous heat method mDSC Cryo-TEM Light scattering PDMAEMA
Κάτοχος πνευματικών δικαιωμάτων:	2022 Elsevier B.V. All rights reserved.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1016/j.jddst.2022.103830
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο