Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	P(OEGMA-co-LMA) hyperbranched amphiphilic copolymers as self-assembled nanocarriers
Δημιουργός/Συγγραφέας:	Balafouti, Anastasia [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios
Εκδότης:	Wiley
Ημερομηνία:	2022-07-01
Γλώσσα:	Αγγλικά
DOI:	10.1002/pol.20220078
Περίληψη:	We report on the synthesis of novel amphiphilic hyperbranched copolymers, namely Hyperbranched-[poly (ethylene glycol) methyl ether methacrylate-co-lauryl methacrylate] (H-[P(OEGMA-co-LMA)]), obtained by reversible addition-fragmentation chain transfer (RAFT) polymerization utilizing the divinylmonomer, ethylene glycol dimethacrylate (EGDMA) as the branching agent. Molecular characterization by size exclusion chromatography (SEC) and protonnuclear magnetic resonance (1H-NMR) spectroscopy indicated the success of thepolymerization. The self-assembly behavior in aqueous media was investigated bylight scattering techniques and fluorescencespectroscopy. Thehyperbranchedcopolymers form multimolecular aggregates of nanoscale dimensions with alow critical aggregation concentration. In addition, the model hydrophobic drug, curcumin (CUR), known also for its intrinsic fluorescence properties, was used inorder to investigate the H-[P(OEGMA-co-LMA)] copolymers drug encapsulationability. Curcumin is successfully loadedinto the polymeric nanoparticles, asconfirmed by dynamic light scattering and UV–Vis spectroscopy. Interestingly, curcumin hydrophobic interactions with the hyperbranched copolymers resultin more well-defined co-assembled nanostructures, in terms of size and sizedistribution. The mixed copolymer-CURnano-assemblies consist of small sizenanoparticles (<100 nm) which exhibit relatively high size uniformity, colloidalstability and fluorescent properties. Overall, results signify that the biocompatibleH-[P(OEGMA-co-LMA)] nanostructures could potentially serve as nanocarriersystems for drug delivery andbio-imaging applications.
Τίτλος πηγής δημοσίευσης:	Journal of Polymer Science
Τόμος/Κεφάλαιο:	60
Τεύχος:	13
Σελίδες:	1931-1943
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Βιοτεχνολογία[EN] Biotechnology
Λέξεις-Κλειδιά:	Curcumin Drug encapsulation Hyperbranched amphiphilic copolymers Reversibleaddition-fragmentation chain transfer polymerization Self-assembly
Κάτοχος πνευματικών δικαιωμάτων:	2022 Wiley Periodicals LLC
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1002/pol.20220078
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο