Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Nano-Sized Polyelectrolyte Complexes Formed between Poly(vinyl benzyl trimethyl ammonium chloride) and Insulin
Δημιουργός/Συγγραφέας:	Chroni, Angeliki [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios
Εκδότης:	MDPI
Ημερομηνία:	2022
Γλώσσα:	Αγγλικά
DOI:	10.3390/micro2020020
Περίληψη:	Novel biohybrid homo-polyelectrolyte-based nanocarriers were formed by the complexation of insulin (INS) with a biocompatible and cationic polyelectrolyte, namely, poly(vinyl benzyl trimethylammonium chloride) (PVBTMAC). According to light-scattering techniques, the hydrophilic PVBTMAC homo-polyelectrolyte forms single chains in aqueous media. The resulting biohybrid PVBTMAC/INS nanocarriers were formed via electrostatic co-assembly. The effects of polyelectrolyte structure and content on the characteristics of the formed PVBTMAC/INS complexes were studied. A significant aggregation tendency of the PVBTMAC/INS complexes was observed, based on the physicochemical results, especially at high protein concentration, corroborating the effective electrostatic interaction of INS with the cationic polyelectrolyte. The physicochemical properties of the formed PVBTMAC/INS nanocarriers depended on the concentration of the stock polymer and INS solutions. A neat PVBTMAC homo-polymer and PVBTMAC/INS nanocarriers demonstrated good serum stability in the presence of fetal bovine serum (FBS) proteins. Fluorescence spectroscopy (FS) studies revealed no INS conformational changes after its complexation with the cationic PVBTMAC polyelectrolyte. The obtained PVBTMAC/INS complexes demonstrated considerable and promising characteristics for potential use as insulin delivery systems.
Τίτλος πηγής δημοσίευσης:	Micro
Τόμος/Κεφάλαιο:	2
Τεύχος:	2
Σελίδες:	313-324
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry
Λέξεις-Κλειδιά:	Cationic polyelectrolytes Polyelectrolyte–protein complexes Polyelectrolyte–insulin complexes Insulin Nanocarriers
Κάτοχος πνευματικών δικαιωμάτων:	2022 by the authors. Licensee MDPI, Basel, Switzerland.
Ηλεκτρονική διεύθυνση με ανοικτή πρόσβαση (link):	https://www.mdpi.com/2673-8023/2/2/20
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο