Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Regulating MDA-MB-231 breast cancer cell adhesion on laser-patterned surfaces with micro- and nanotopography
Δημιουργός/Συγγραφέας:	Kanidi, M. Papadimitropoulou, A. Charalampous, C. Chakim, Z. Tsekenis, G. Sinani, A. [EL] Ριζιώτης, Χρήστος Δ.[EN] Riziotis, Christos [EL] Κάνδυλα, Μαρία[EN] Kandyla, Maria
Εκδότης:	AVS (American Vacuum Society)
Ημερομηνία:	2022
Γλώσσα:	Αγγλικά
DOI:	10.1116/6.0001564
Περίληψη:	Breast cancer is the most common type of cancer observed in women. Communication with the tumor microenvironment allows invading breast cancer cells, such as triple negative breast cancer cells, to adapt to specific substrates. The substrate topography modulates the cellular behavior among other factors. Several different materials and micro/nanofabrication techniques have been employed to develop substrates for cell culture. Silicon-based substrates present a lot of advantages as they are amenable to a wide range of processing techniques and they permit rigorous control over the surface structure. We investigate and compare the response of the triple negative breast cancer cells (MDA-MB-231) on laser-patterned silicon substrates with two different topographical scales, i.e., the micro- and the nanoscale, in the absence of any other biochemical modification. We develop silicon surfaces with distinct morphological characteristics by employing two laser systems with different pulse durations (nanosecond and femtosecond) and different processing environments (vacuum, SF6 gas, and water). Our findings demonstrate that surfaces with microtopography are repellent, while those with nanotopography are attractive for MDA-MB-231 cell adherence.
Τίτλος πηγής δημοσίευσης:	Biointerfaces
Τόμος/Κεφάλαιο:	17
Τεύχος:	2
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Νανοτεχνολογία[EN] Nanotechnology [EL] Κυτταρολογία[EN] Cytology [EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens)
Λέξεις-Κλειδιά:	Breast cancer Nanotopography Laser-patterned surfaces MDA-MB-231 Silicon-based substrates
EU Grant:	European Social Fund—ESF
EU Grant identifier:	MIS 5048213
Κάτοχος πνευματικών δικαιωμάτων:	2022 Author(s). Published under an exclusive license by the AVS.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://pubs.aip.org/avs/bip/article/17/2/021002/2835362/Regulating-MDA-MB-231-breast-cancer-cell-adhesion
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο