Εξειδίκευση τύπου :	Άρθρο σε περιοδικό τύπο
Τίτλος:	A Multilevel Study of Eupatorin and Scutellarein as Anti-Amyloid Agents in Alzheimer's Disease
Δημιουργός/Συγγραφέας:	Rizou, Aikaterini E I Nasi, Georgia I Paikopoulos, Yiorgos Bezantakou, Dimitra S Vraila, Konstantina D Spatharas, Panagiotis M Dimaki, Virginia D. Papandreou, Nikos C Lamari, Fotini N. [EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki Iconomidou, Vassiliki A
Ημερομηνία:	2023-05-04
Γλώσσα:	Αγγλικά
ISSN:	2227-9059
DOI:	10.3390/biomedicines11051357
Άλλο:	37239029
Περίληψη:	Today, Alzheimer's disease (AD)-the most common neurodegenerative disorder, which affects 50 million people-remains incurable. Several studies suggest that one of the main pathological hallmarks of AD is the accumulation of abnormal amyloid beta (Aβ) aggregates; therefore, many therapeutic approaches focus on anti-Aβ aggregation inhibitors. Taking into consideration that plant-derived secondary metabolites seem to have neuroprotective effects, we attempted to assess the effects of two flavones-eupatorin and scutellarein-on the amyloidogenesis of Aβ peptides. Biophysical experimental methods were employed to inspect the aggregation process of Aβ after its incubation with each natural product, while we monitored their interactions with the oligomerized Aβ through molecular dynamics simulations. More importantly, we validated our in vitro and in silico results in a multicellular organismal model-namely, Caenorhabditis elegans-and we concluded that eupatorin is indeed able to delay the amyloidogenesis of Aβ peptides in a concentration-dependent manner. Finally, we propose that further investigation could lead to the exploitation of eupatorin or its analogues as potential drug candidates.
Τίτλος πηγής δημοσίευσης:	Biomedicines
Τόμος/Κεφάλαιο:	11
Τεύχος:	5
Θεματική Κατηγορία:	[EL] Βιοχημεία[EN] Biochemistry [EL] Φαρμακευτική[EN] Pharmacy and materia medica [EL] Δομική Βιολογία[EN] Structural Biology [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Βιοτεχνολογία[EN] Biotechnology
Λέξεις-Κλειδιά:	Alzheimer’s disease Caenorhabditis elegans amyloid beta peptide eupatorin model organism molecular dynamics natural products scutellarein
EU Grant:	“Competitiveness, Entrepreneurship and Innovation, under the call “RESEARCH—CREATE—INNOVATE”
EU Grant identifier:	T1EDK-00353
Κάτοχος πνευματικών δικαιωμάτων:	© 2023 by the authors
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/)
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/2227-9059/11/5/1357
Σημειώσεις:	This research was co-financed by the European Union and Greek national funds through the Operational Program “Competitiveness, Entrepreneurship and Innovation”, under the call “RESEARCH—CREATE—INNOVATE” (project code: T1EDK-00353).
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο