Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Maternal Dietary Protein Patterns and Neonatal Anthropometrics: A Prospective Study with Insights from NMR Metabolomics in Amniotic Fluid
Δημιουργός/Συγγραφέας:	Kyrkou, Charikleia Fotakis, Charalambos Dimitropoulou, Aristea Tsakoumaki, Foteini [EL] Ζουμπουλάκης, Παναγιώτης[EN] Zoumpoulakis, Panagiotis Menexes, Georgios Biliaderis, Costas G Athanasiadis, Apostolos P Michaelidou, Alexandra-Maria
Ημερομηνία:	2023-08-29
Γλώσσα:	Αγγλικά
ISSN:	2218-1989
DOI:	10.3390/metabo13090977
Άλλο:	37755257
Περίληψη:	This study aimed to characterize dietary protein patterns (DPPs) in a sample pool of 298 well-nourished pregnant women and explore potential associations between DPPs and neonatal anthropometrics. Maternal dietary data were collected using a validated food frequency questionnaire. Neonatal anthropometrics were abstracted from health booklets. A hierarchical cluster analysis identified three DPPs: "Dairy-focused", "Med-fusion", and "Traditional-inspired". The "Dairy-focused" DPP exhibited the highest protein intake (p < 0.001), predominantly animal protein (p < 0.001), while the "Traditional-inspired" DPP presented higher plant protein (p < 0.001) and fiber intakes (p < 0.001), and, therefore, a reduced carbohydrate-to-fiber quotient (p < 0.001). The "Med-fusion" DPP had the lowest protein-to-fat ratio (p < 0.001). Infants of women following the "Dairy-focused" DPP had the highest birth height centiles (p = 0.007) and the lowest ponderal index (p = 0.003). The NMR-metabolomics approach was implemented on a subset of women that provided amniotic fluid (AF) specimens (n = 62) to elucidate distinct metabolic signatures associated with DPPs. PCA and OPLS-DA models verified the adherence to three DPPs, revealing that the levels of several amino acids (AAs) were the highest in "Dairy-focused", reflecting its protein-rich nature. The "Traditional-inspired" DPP showed decreased AAs and glucose levels. This knowledge may contribute to optimizing maternal dietary recommendations. Further research is needed to validate these findings and better understand the relationships between maternal diet, AF metabolic signature, and neonatal anthropometrics.
Τίτλος πηγής δημοσίευσης:	Metabolites
Τόμος/Κεφάλαιο:	13
Τεύχος:	9
Θεματική Κατηγορία:	[EL] Βιοχημεία[EN] Biochemistry [EL] Γενετική[EN] Genetics [EL] Φυσιολογία παιδιών και βρεφών[EN] Physiology of children and infants [EL] Ανθρωπολογία[EN] Anthropology [EL] Βιοπληροφορική[EN] Bioinformatics
Λέξεις-Κλειδιά:	Maternal nutrition Dietary patterns Protein quality Branched-chain amino acids Glucose Infant growth Ponderal index Birth height centiles Birthweight Nutrients
Κάτοχος πνευματικών δικαιωμάτων:	© 2023 by the authors.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/2218-1989/13/9/977
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο