Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Structural modeling of protein ensembles between E3 RING ligases and SARS-CoV-2: The role of zinc binding domains
Δημιουργός/Συγγραφέας:	[EL] Χασάπης, Χρήστος[EN] Chasapis, Christos Perlepes, Spyros P. Bjørklund, Geir Peana, Massimiliano
Ημερομηνία:	2023-01
Γλώσσα:	Αγγλικά
ISSN:	0946672X
DOI:	10.1016/j.jtemb.2022.127089
Άλλο:	36209710
Περίληψη:	The ubiquitin system is a modification process with many different cellular functions including immune signaling and antiviral functions. E3 ubiquitin ligases are enzymes that recruit an E2 ubiquitin-conjugating enzyme bound to ubiquitin in order to catalyze the transfer of ubiquitin from the E2 to a protein substrate. The RING E3s, the most abundant type of ubiquitin ligases, are characterized by a zinc (II)-binding domain called RING (Really Interesting New Gene). Viral replication requires modifying and hijacking key cellular pathways within host cells such as cellular ubiquitination. There are well-established examples where a viral proteins bind to RING E3s, redirecting them to degrade otherwise long-lived host proteins or inhibiting E3's ubiquitination activity. Recently, three binary interactions between SARS-CoV-2 proteins and innate human immune signaling Ε3 RING ligases: NSP15-RNF41, ORF3a-TRIM59 and NSP9-MIB1 have been experimentally established.
Τίτλος πηγής δημοσίευσης:	Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
Τόμος/Κεφάλαιο:	75
Θεματική Κατηγορία:	[EL] Δομική Βιολογία[EN] Structural Biology [EL] Χημική μηχανική[EN] Chemical engineering [EL] Βιοχημεία[EN] Biochemistry [EL] Ανοσολογία[EN] Immunology
Λέξεις-Κλειδιά:	E3 RING ligases SARS-CoV-2 Zinc binding RING domains Haddock
EU Grant:	Fondo di Ateneo per la ricerca 2020, FAR 2020
Κάτοχος πνευματικών δικαιωμάτων:	© 2022 Elsevier GmbH. All rights reserved.
Ηλεκτρονική διεύθυνση με ανοικτή πρόσβαση (link):	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531365/
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.sciencedirect.com/science/article/pii/S0946672X22001699?via%3Dihub#sec0040
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο