Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	A quest for the stereo-electronic requirements for selective agonism for the neurotrophin receptors TrkA and TrkB in 17-spirocyclic-dehydroepiandrosterone derivatives
Δημιουργός/Συγγραφέας:	Narducci, Daniele Charou, Despoina Rodgakis, Thanasis Zota, Ioanna Bafiti, Vivi [EL] Ζερβού, Μαρία[EN] Zervou, Maria [EL] Κατσίλα, Θεοδώρα[EN] Katsila, Theodora Gravanis, Achille [EL] Προύσης, Κυριάκος[EN] Prousis, Kyriakos Charalampopoulos, Ioannis [EL] Καλογεροπούλου, Θεοδώρα[EN] Calogeropoulou, Theodora
Ημερομηνία:	2023
Γλώσσα:	Αγγλικά
ISSN:	1662-5099
DOI:	10.3389/fnmol.2023.1244133
Άλλο:	37840771
Περίληψη:	The neurotrophin system plays a pivotal role in the development, morphology, and survival of the nervous system, and its dysregulation has been manifested in numerous neurodegenerative and neuroinflammatory diseases. Neurotrophins NGF and BDNF are major growth factors that prevent neuronal death and synaptic loss through binding with high affinity to their specific tropomyosin-related kinase receptors namely, TrkA and TrkB, respectively. The poor pharmacokinetic properties prohibit the use of neurotrophins as therapeutic agents. Our group has previously synthesized BNN27, a prototype small molecule based on dehydroepiandrosterone, mimicking NGF through the activation of the TrkA receptor.
Τίτλος πηγής δημοσίευσης:	Frontiers in molecular neuroscience
Τόμος/Κεφάλαιο:	16
Θεματική Κατηγορία:	[EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Νευροεπιστήμη. Βιολογική ψυχιατρική. Νευροψυχιατρική[EN] Neurosciences. Biological psychiatry. Neuropsychiatry [EL] Βιοτεχνολογία[EN] Biotechnology
Λέξεις-Κλειδιά:	DHEA derivatives TrkA TrkB Neurodegeneration Neuroprotection Neurotrophin mimetics Receptor agonists Signaling
EU Grant:	Marie Skłodowska-Curie
EU Grant identifier:	no. 765704
Κάτοχος πνευματικών δικαιωμάτων:	© 2023 Narducci, Charou, Rogdakis, Zota, Bafiti, Zervou, Katsila, Gravanis, Prousis, Charalampopoulos and Calogeropoulou
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.3389/fnmol.2023.1244133
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο